THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications published on December 14th, 2023

Patent applications for THE REGENTS OF THE UNIVERSITY OF CALIFORNIA on December 14th, 2023

HIGH-TRANSCONDUCTANCE ORGANIC ELECTROCHEMICAL TRANSISTOR (OECT)-BASED SENSORS AND METHODS OF USE (18249716)

Main Inventor

Alireza Khademhosseini

Brief explanation

The patent application describes a sensor device that uses a circular-shaped gate electrode and source and drain electrodes with a curvy and wavy pattern. This design allows for the creation of high-transconductance organic electrochemical transistors (OECTs) for multiplexed biosensors.

• The sensor device uses a circular-shaped gate electrode and source and drain electrodes with a curvy and wavy pattern.
• The arrangement of the source and drain electrodes around the gate electrode enables the creation of high-transconductance OECTs.
• This design allows for the development of multiplexed OECT-based biosensors for high-throughput screening of multiple biomarkers/biomolecules.
• The platform can be used for point-of-care applications, wearable biosensing, and minimally-invasive biosensing with microneedles or a catheter/probe as a carrier for the high-transconductance OECTs.

Potential Applications

The technology described in this patent application has several potential applications:

• Point-of-care applications: The high-transconductance OECT-based biosensors can be used for rapid and on-site detection of biomarkers, enabling quick diagnosis and treatment decisions.
• Wearable biosensing: The sensor device can be integrated into wearable devices, such as smartwatches or fitness trackers, to continuously monitor biomarkers and provide real-time health information.
• Minimally-invasive biosensing: The high-transconductance OECTs can be incorporated into microneedles or catheters/probes for minimally-invasive monitoring of biomarkers, reducing the need for invasive procedures.

Problems Solved

The technology described in this patent application solves several problems:

• High-transconductance OECTs: The curvy and wavy pattern of the source and drain electrodes allows for the creation of high-transconductance OECTs, which improves the sensitivity and accuracy of the biosensors.
• Multiplexed biosensing: The arrangement of the electrodes enables the development of multiplexed OECT-based biosensors, allowing for the simultaneous detection of multiple biomarkers or biomolecules.
• Versatile applications: The platform can be used for various applications, including point-of-care, wearable, and minimally-invasive biosensing, providing flexibility and convenience in different healthcare settings.

Benefits

The technology described in this patent application offers several benefits:

• Improved sensitivity and accuracy: The high-transconductance OECTs provide enhanced sensitivity and accuracy in detecting biomarkers, enabling early disease detection and personalized medicine.
• High-throughput screening: The multiplexed OECT-based biosensors allow for high-throughput screening of multiple biomarkers or biomolecules, increasing efficiency and reducing time and cost.
• Versatile and flexible: The platform can be used in different healthcare settings, including point-of-care, wearable, and minimally-invasive applications, providing versatility and flexibility in monitoring biomarkers.

Abstract

An organic electrochemical transistor (OECT)-based sensor device is disclosed that uses circular-shaped gate electrode and source and drain electrodes that at least partially surround the gate electrode and have an undulating pattern that is generally described as curvy and wavy (CW). The arrangement of the source and drain electrodes around the gate electrode provides the ability to obtain high-transconductance OECT (HT-OECT). With the HT-OECT sensor design, multiplexed OECT-based biosensors can be created for high-throughput screening applications of multiple biomarkers/biomolecules. This platform can be used for point-of-care applications, wearable biosensing, and minimally-invasive biosensing with microneedles or a catheter/probe as a carrier for HT-OECT(s).

SILICASOME NANOCARRIER FOR METAL-BASED DRUG DELIVERY (18250727)

Main Inventor

Andre E. Nel

Brief explanation

The patent application describes drug delivery vehicles that contain metal-based therapeutic agents. These vehicles consist of silica nanoparticles with cavities, a metal-based chemotherapeutic drug, and a lipid bilayer that encapsulates the nanoparticle.

• Drug delivery vehicles with metal-based therapeutic agents are provided.
• The vehicles are made of silica nanoparticles with cavities.
• The nanoparticles have an outside surface that is in fluid communication with the cavities.
• The vehicles contain a metal-based chemotherapeutic drug, such as platinum-based drugs.
• The drug is either on the surface of the nanoparticle or within the cavities.
• The drug is cationic and metal-based.
• The vehicles are sealed and encapsulated by a lipid bilayer.

Potential Applications

• Targeted drug delivery for cancer treatment.
• Enhanced efficacy of metal-based chemotherapeutic drugs.
• Controlled release of drugs within the body.

Problems Solved

• Improves the delivery and effectiveness of metal-based chemotherapeutic drugs.
• Provides a targeted drug delivery system for specific cells or tissues.
• Enhances drug stability and reduces side effects.

Benefits

• Increased therapeutic efficacy of metal-based chemotherapeutic drugs.
• Reduced toxicity and side effects.
• Improved drug stability and controlled release.
• Targeted delivery to specific cells or tissues.

Abstract

In various embodiments, drug delivery vehicles that contain one or more metal-based therapeutic agents are provided. In certain embodiments, the drug delivery vehicle comprises: a silica nanoparticle comprising one or more cavities disposed within the nanoparticle and an outside surface where the one or more cavities are in fluid communication with the outside surface of the nanoparticle; a metal-based (e.g., platinum-based) chemotherapeutic drug disposed on the surface of the nanoparticle and/or within the one or more cavities of the nanoparticle where the drug comprises a cationic, metal-based drug; and a lipid bilayer disposed on the surface of the nanoparticle where the lipid bilayer fully encapsulates and seals the nanoparticle.

STREPTOCOCCAL GlcNAc-LACKING GLYCOPOLYPEPTIDES, CELL WALL CARBOHYDRATES, STREPTOCOCCUS VACCINES, AND METHODS FOR MAKING AND USING THEM (18234742)

Main Inventor

Victor Nizet

Brief explanation

The patent application describes vaccines, pharmaceutical compounds, and formulations for diagnosing, preventing, treating, or improving Group A (GAS), Group C (GCS), or Group A (GGS) infections, or other pathogenic infections. It also includes compositions such as diagnostic tests, assays, immunoassays, and test strips, as well as methods for detecting or diagnosing the presence of a Streptococcal infection or other pathogenic infections.

• Vaccines, pharmaceutical compounds, and formulations for Group A (GAS), Group C (GCS), or Group A (GGS) infections
• Compositions for diagnostic tests, assays, immunoassays, and test strips
• Methods for detecting or diagnosing Streptococcal infections or other pathogenic infections

Potential Applications

• Medical industry: The invention can be used in the development of vaccines and pharmaceutical compounds for diagnosing, preventing, treating, or ameliorating Group A (GAS), Group C (GCS), or Group A (GGS) infections, or other pathogenic infections.
• Diagnostic industry: The invention provides compositions and methods for detecting or diagnosing the presence of Streptococcal infections or other pathogenic infections, which can be used in diagnostic tests, assays, immunoassays, and test strips.

Problems Solved

• Lack of effective vaccines and pharmaceutical compounds for Group A (GAS), Group C (GCS), or Group A (GGS) infections, or other pathogenic infections.
• Limited options for detecting or diagnosing Streptococcal infections or other pathogenic infections.

Benefits

• Improved ability to diagnose, prevent, treat, or ameliorate Group A (GAS), Group C (GCS), or Group A (GGS) infections, or other pathogenic infections.
• Enhanced accuracy and efficiency in detecting or diagnosing the presence of Streptococcal infections or other pathogenic infections.

Abstract

In alternative embodiments, the invention provides vaccines, pharmaceutical compounds and formulations for diagnosing, preventing, treating or ameliorating Group A (GAS), Group C (GCS), or Group A (GGS), infections, or other pathogenic infections. In alternative embodiments, the invention provides compositions such as diagnostic tests, assays, immunoassays and test strips, and methods, for detecting or diagnosing the presence of a Streptococcal infection, e.g., Group A (GAS), Group C (GCS), or Group A (GGS), infections, or other pathogenic infections.

SIRNA-NANOBOWL-MEDIATED INTERVENTION OF COVID-19 (18251227)

Main Inventor

Deependra Kumar Ban

Brief explanation

Abstract:

The patent application describes methods, systems, and devices related to siRNA-based nanobowl-mediated intervention for COV-ID-19.

• siRNA-based nanobowl-mediated intervention for COV-ID-19 is the focus of the patent application.
• The methods, systems, and devices described in the patent application aim to provide a novel approach for combating COV-ID-19.
• The intervention involves the use of small interfering RNA (siRNA) delivered through nanobowls.
• The siRNA is designed to target specific genes or viral components of COV-ID-19.
• The nanobowls act as carriers to deliver the siRNA to the target cells.
• The patent application provides details on the design and synthesis of the siRNA and nanobowls.
• The methods, systems, and devices described in the patent application have potential applications in the treatment and prevention of COV-ID-19.

Potential Applications:

• Treatment of COV-ID-19: The siRNA-based nanobowl-mediated intervention can be used as a therapeutic approach to treat individuals infected with COV-ID-19.
• Prevention of COV-ID-19: The intervention can also be utilized as a preventive measure to reduce the risk of COV-ID-19 infection.
• Research and Development: The methods, systems, and devices described in the patent application can be used in research and development efforts related to COV-ID-19.

Problems Solved:

• Lack of effective treatments: The siRNA-based nanobowl-mediated intervention provides a potential solution to the lack of effective treatments for COV-ID-19.
• Limited preventive measures: The intervention offers a new approach to prevent COV-ID-19 infection, addressing the limited preventive measures available.

Benefits:

• Targeted intervention: The siRNA-based approach allows for targeted intervention by specifically targeting genes or viral components of COV-ID-19.
• Enhanced delivery: The use of nanobowls as carriers improves the delivery of siRNA to the target cells, increasing the effectiveness of the intervention.
• Potential versatility: The methods, systems, and devices described in the patent application can be adapted for use with other viral infections, potentially providing a versatile solution.

Abstract

Provided are methods, systems, and devices that pertain to siRNA-based nanobowl-mediated intervention for COV-ID-19.

Device for Optimization of Microorganism Growth in Liquid Culture (18234171)

Main Inventor

Alexandra Perebikovsky

Brief explanation

The patent application describes a system and method for growing microorganisms in liquid culture using a microfluidic cartridge that can be oscillated back and forth along an oscillation path.

• The system includes a driving apparatus that houses and oscillates the microfluidic cartridge.
• The microfluidic cartridge has at least one incubation chamber where the microorganism and growth medium are disposed.
• The incubation chamber is oscillated back and forth along an oscillation path using a preferred oscillation protocol to mix the microorganism and growth medium.

Potential applications of this technology:

• Biotechnology research and development
• Pharmaceutical industry for drug discovery and development
• Environmental monitoring and analysis
• Food and beverage industry for quality control and testing

Problems solved by this technology:

• Provides a more efficient and controlled method for growing microorganisms in liquid culture
• Allows for better mixing of the microorganism and growth medium, leading to improved growth and productivity
• Reduces the risk of contamination and cross-contamination during the growth process

Benefits of this technology:

• Faster and more consistent growth of microorganisms
• Improved control over growth conditions
• Reduced risk of contamination and cross-contamination
• Higher productivity and yield in biotechnology and pharmaceutical applications

Abstract

There is described a system for growing a microorganism in liquid culture, the system comprising: a driving apparatus configured to house and oscillate a microfluidic cartridge; and a microfluidic cartridge comprising at least one incubation chamber, such that when the system is in use, the incubation chamber may be oscillated back and forth along an oscillation path using a preferred oscillation protocol. There is also described a method of growing a microorganism in liquid culture, the method comprising disposing a microorganism and suitable growth medium into an incubation chamber; and mixing the microorganism and growth medium by oscillating the incubation chamber back and forth along an oscillation path using a preferred oscillation protocol. There is also described a microfluidic cartridge that may be used to grow microorganisms using the system and methods described above.

DESIGN METHODS AND MOTION CONTROL ALGORITHMS FOR IMPACT-RESILIENT MOBILE ROBOTS (18034603)

Main Inventor

Konstantinos KARYDIS

Brief explanation

The patent application describes an apparatus and method for detecting and recovering from collisions involving aerial vehicles. The apparatus includes an arm, a flexible member, and a sensing system. A processor is used to receive a collision signal, regain control of the collision-resilient robot, and plan a post-collision trajectory using a global search-based planner.

• The apparatus is designed to detect collisions involving aerial vehicles and recover from them.
• It includes an arm, a flexible member, and a sensing system to facilitate collision detection and recovery.
• A processor is used to receive collision signals and regain control of the robot after a collision.
• The processor also plans a post-collision trajectory for the robot using a global search-based planner.

Potential Applications

This technology can have various applications in the field of aerial vehicles, including:

• Drone delivery services: The collision detection and recovery system can help ensure the safe delivery of packages by drones, even in the event of collisions.
• Aerial surveillance: Drones equipped with this technology can continue their surveillance operations even after colliding with obstacles, minimizing downtime.
• Search and rescue missions: The collision-resilient robots can navigate through challenging environments and recover from collisions, making them suitable for search and rescue operations.

Problems Solved

The technology addresses several problems associated with collisions involving aerial vehicles:

• Collision detection: The apparatus provides a reliable method for detecting collisions, allowing for prompt response and recovery.
• Collision recovery: By regaining control of the robot and planning a post-collision trajectory, the technology enables the robot to continue its mission or return to a safe location.
• Downtime reduction: The system minimizes downtime caused by collisions, ensuring the continuity of operations and reducing potential delays.

Benefits

The technology offers several benefits in the field of aerial vehicles:

• Enhanced safety: By promptly detecting and recovering from collisions, the technology improves the overall safety of aerial vehicles and their operations.
• Increased reliability: The collision-resilient robot can continue its mission or return to safety, increasing the reliability of aerial vehicle systems.
• Efficiency improvement: Minimizing downtime and delays due to collisions improves the efficiency of aerial vehicle operations, such as drone deliveries or surveillance missions.

Abstract

An apparatus and method for detecting a collision of an aerial vehicle and recovery from the collision is disclosed. An apparatus for use in an aerial vehicle includes an arm, a flexible member and a sensing system. A processor is configured to receive a collision signal after deformation of the collision-resilient robot from a collision, recover control of the collision-resilient robot after the collision, and plan a post-collision trajectory for the collision-resilient robot using a global search-based planner.

HLA CLASS II-RESTRICTED TCRS AGAINST THE KRAS G12>V ACTIVATING MUTATION ([[18035160. HLA CLASS II-RESTRICTED TCRS AGAINST THE KRAS G12>V ACTIVATING MUTATION simplified abstract (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)|18035160]])

Main Inventor

Stephen P. Schoenberger

Brief explanation

The present invention is related to engineered T cell receptor (TCR) proteins and methods of treating cancer using these proteins. It also includes chimeric antigen receptor expressing T cell (CAR-T) comprising specific amino acid sequences.

• Engineered T cell receptor (TCR) proteins and nucleic acids are provided.
• Vectors and host cells for expressing the TCR proteins are included.
• Methods of treating cancer using the TCR proteins are described.
• Chimeric antigen receptor expressing T cell (CAR-T) with specific amino acid sequences are disclosed.
• The TCR proteins and CAR-T are specific for a KRAS G12>V mutation peptide.
• The invention includes antigen-MHC binding portions and full-length portions of the TCR proteins.

Potential Applications

• Treatment of cancer, specifically targeting KRAS G12>V mutation peptide.
• Development of personalized immunotherapies for cancer patients.
• Enhancement of the body's immune response against cancer cells.

Problems Solved

• Lack of effective treatments for cancer patients with KRAS G12>V mutation.
• Limited options for personalized immunotherapies.
• Difficulty in targeting specific cancer mutations.

Benefits

• Improved treatment options for cancer patients with KRAS G12>V mutation.
• Potential for personalized and targeted immunotherapies.
• Enhanced immune response against cancer cells.

Abstract

The present invention includes engineered T cell receptor (TCR) proteins, nucleic acids, vectors, host cells, methods of treating cancer, and chimeric antigen receptor expressing T cell (CAR-T) comprising an alpha chain CDR3 having the amino acid sequence of SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, or 23 and/or a beta chain CDR3 having the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, or 24, wherein the TCR is specific for a KRAS G12>V mutation peptide, antigen-MHC binding portions, and full length portions of the same.

RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USE THEREOF (18130199)

Main Inventor

Schaked Omer Halperin

Brief explanation

The present patent application describes a fusion polypeptide that combines an RNA-guided endonuclease and an error-prone DNA polymerase. This fusion polypeptide is used in a system along with a guide RNA to introduce mutations in a target DNA sequence. The application also describes a method of mutagenizing a target polynucleotide using this fusion polypeptide system.

• Fusion polypeptide: A combination of an RNA-guided endonuclease and an error-prone DNA polymerase.
• System: The fusion polypeptide is used together with a guide RNA to introduce mutations in a target DNA sequence.
• Cell: The patent application also covers a cell that contains the fusion polypeptide or the fusion polypeptide system.
• Method: The application describes a method of mutagenizing a target polynucleotide using the fusion polypeptide system.

Potential applications of this technology:

• Genetic engineering: The fusion polypeptide system can be used to introduce specific mutations in target DNA sequences, allowing for precise genetic modifications.
• Biomedical research: This technology can be used to study the effects of specific mutations on gene function and disease development.
• Drug discovery: The ability to introduce mutations in target DNA sequences can aid in the development of new drugs by studying the effects of these mutations on drug efficacy and resistance.

Problems solved by this technology:

• Precise mutagenesis: The fusion polypeptide system allows for targeted introduction of mutations in DNA sequences, providing a more precise and controlled method compared to traditional mutagenesis techniques.
• Efficiency: The fusion polypeptide system combines the activities of an RNA-guided endonuclease and an error-prone DNA polymerase, increasing the efficiency of mutagenesis.
• Specificity: The guide RNA directs the fusion polypeptide to the desired target DNA sequence, ensuring that mutations are introduced at the intended location.

Benefits of this technology:

• Precision: The fusion polypeptide system allows for precise introduction of mutations at specific locations in DNA sequences.
• Efficiency: The combination of an RNA-guided endonuclease and an error-prone DNA polymerase increases the efficiency of mutagenesis.
• Versatility: The fusion polypeptide system can be used in various applications, including genetic engineering, biomedical research, and drug discovery.

Abstract

The present disclosure provides a fusion polypeptide comprising: a) an enzymatically active RNA-guided endonuclease that introduces a single-stranded break in a target DNA; and b) an error-prone DNA polymerase. The present disclosure provides a system comprising: a) a fusion polypeptide of the present disclosure; and b) a guide RNA. The present disclosure provides a cell comprising a fusion polypeptide of the present disclosure, or a system of the present disclosure. The present disclosure provides a method of mutagenizing a target polynucleotide.

RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USE THEREOF (18130202)

Main Inventor

Schaked Omer Halperin

Brief explanation

The present patent application describes a fusion polypeptide that combines an RNA-guided endonuclease and an error-prone DNA polymerase. This fusion polypeptide is used in a system with a guide RNA to introduce mutations in a target DNA sequence. The application also includes a method for mutagenizing a target polynucleotide using this fusion polypeptide.

• Fusion polypeptide: The patent application describes a fusion polypeptide that combines an RNA-guided endonuclease and an error-prone DNA polymerase.
• System: The fusion polypeptide is used in a system with a guide RNA to introduce mutations in a target DNA sequence.
• Cell: The patent application also includes a cell that contains the fusion polypeptide or the system described above.
• Method: The application provides a method for mutagenizing a target polynucleotide using the fusion polypeptide.

Potential Applications

This technology has potential applications in various fields, including:

• Genetic research: The fusion polypeptide and system described in the patent application can be used to introduce specific mutations in target DNA sequences, allowing researchers to study the effects of these mutations on gene function.
• Biotechnology: The ability to introduce targeted mutations in DNA sequences can be valuable in biotechnology applications, such as engineering enzymes or modifying organisms for specific purposes.
• Drug development: This technology can be used to create specific mutations in target genes to study their role in disease development or to develop targeted therapies.

Problems Solved

This technology addresses several problems in genetic research and biotechnology:

• Targeted mutagenesis: The fusion polypeptide and system described in the patent application provide a precise and efficient method for introducing mutations in target DNA sequences.
• Error-prone DNA polymerase: The inclusion of an error-prone DNA polymerase in the fusion polypeptide allows for the introduction of random mutations, expanding the range of mutations that can be generated.
• Simplified process: The fusion polypeptide and system described in the patent application streamline the process of mutagenizing target polynucleotides, making it more accessible and efficient for researchers.

Benefits

The use of this technology offers several benefits:

• Precision: The fusion polypeptide and system allow for precise targeting of specific DNA sequences, ensuring that mutations are introduced at the desired locations.
• Efficiency: The fusion polypeptide and system provide an efficient method for introducing mutations, reducing the time and resources required for genetic research and biotechnology applications.
• Versatility: The inclusion of an error-prone DNA polymerase in the fusion polypeptide allows for the generation of a wide range of mutations, increasing the versatility of this technology for various applications.

Abstract

The present disclosure provides a fusion polypeptide comprising: a) an enzymatically active RNA-guided endonuclease that introduces a single-stranded break in a target DNA; and b) an error-prone DNA polymerase. The present disclosure provides a system comprising: a) a fusion polypeptide of the present disclosure; and b) a guide RNA. The present disclosure provides a cell comprising a fusion polypeptide of the present disclosure, or a system of the present disclosure. The present disclosure provides a method of mutagenizing a target polynucleotide.

METHODS AND COMPOSITIONS FOR THE PRODUCTION OF RHAMNOLIPID (18324283)

Main Inventor

Deepika AWASTHI

Brief explanation

The present invention is a method for producing a substance called rhamnolipid. The method involves using a genetically modified host cell that has been modified to express certain genes (RhlYZAB) in a growth or culture medium. The host cell is then grown or cultured, resulting in the production of rhamnolipid. The rhamnolipid can be recovered from the host cell or from the growth or culture medium if desired. In some cases, the host cell used in the method is a type of bacteria called a methanotroph.

• Method for producing rhamnolipid
• Involves using a genetically modified host cell
• Host cell expresses genes (RhlYZAB) in a growth or culture medium
• Host cell is grown or cultured to produce rhamnolipid
• Rhamnolipid can be recovered from the host cell or growth/culture medium
• Host cell used in the method can be a methanotroph bacteria

Potential Applications

• Production of rhamnolipid for various industrial applications
• Use of rhamnolipid as a biosurfactant in industries such as oil and gas, agriculture, and cosmetics
• Potential use of rhamnolipid in environmental remediation processes

Problems Solved

• Provides a method for efficient production of rhamnolipid
• Allows for the use of a genetically modified host cell to enhance rhamnolipid production
• Offers a way to recover rhamnolipid from the host cell or growth/culture medium

Benefits

• Enables cost-effective production of rhamnolipid
• Provides a sustainable and environmentally friendly method for rhamnolipid production
• Offers potential applications in various industries for the use of rhamnolipid as a biosurfactant

Abstract

The present invention provides for a method for producing a rhamnolipid, the method comprising: (a) providing a genetically modified host cell comprising one or more of RhlYZAB capable of expression in the host cell in a growth or culture medium; (b) growing or culturing the host cell such that the one or more of RhlYZAB are expressed and a rhamnolipid is produced; and (c) optionally recovering the rhamnolipid from the host cell or from the growth or culture medium. In some embodiments, the host cell is a methanotroph.

ASSAYS FOR DETECTION OF ACUTE LYME DISEASE (18332430)

Main Inventor

Charles Y. CHIU

Brief explanation

The patent application is about a method for determining whether a human subject has acute Lyme disease by analyzing the gene expression of cells in a blood sample. 

• The method involves measuring the gene expression of cells in a blood sample obtained from a mammalian subject suspected of having a tick-borne disease.
• Specifically, the method focuses on transcriptome profiling of peripheral blood mononuclear cells.
• The goal is to determine whether the subject has acute Lyme disease based on the gene expression patterns observed in the blood sample.

Potential Applications

This technology has potential applications in the field of diagnosing tick-borne diseases, specifically acute Lyme disease.

• Medical diagnosis: The method can be used by healthcare professionals to accurately diagnose acute Lyme disease in human subjects.
• Treatment planning: The gene expression analysis can provide valuable information for developing personalized treatment plans for patients with acute Lyme disease.
• Research: The method can be used in research studies to better understand the gene expression patterns associated with tick-borne diseases.

Problems Solved

This technology addresses several problems related to the diagnosis of acute Lyme disease.

• Early detection: The method allows for the early detection of acute Lyme disease, enabling prompt treatment and potentially preventing the progression of the disease.
• Accuracy: By analyzing the gene expression patterns, the method provides a more accurate diagnosis compared to traditional diagnostic methods, which may have limitations in sensitivity and specificity.
• Non-invasive: The method utilizes a blood sample, which is a non-invasive and easily accessible specimen, making it convenient for patients and healthcare providers.

Benefits

The use of gene expression analysis for diagnosing acute Lyme disease offers several benefits.

• Improved accuracy: By analyzing gene expression patterns, the method provides a more accurate diagnosis, reducing the risk of misdiagnosis and ensuring appropriate treatment.
• Early intervention: Early detection of acute Lyme disease allows for timely intervention, potentially preventing the development of severe symptoms and complications.
• Personalized treatment: The gene expression analysis can provide insights into the specific molecular mechanisms involved in the disease, enabling personalized treatment plans tailored to individual patients.

Abstract

The present disclosure relates to measuring gene expression of cells of a blood sample obtained from a mammalian subject suspected of having a tick-borne disease. In particular, the present disclosure provides tools for determining whether a human subject has acute Lyme disease by transcriptome profiling a peripheral blood mononuclear cell sample from the subject.

Portable Agricultural Robot for Continuous Apparent Soil Electrical Conductivity Measurements to Improve Irrigation Practices (18203517)

Main Inventor

Konstantinos Karydis

Brief explanation

The patent application describes an apparatus and method for determining soil moisture in agricultural fields. 

• The apparatus includes a mobile platform that moves across the field and a sensor that is physically attached to the platform.
• The sensor measures the apparent electrical conductivity of the soil.
• A control system mounted on the platform is connected to the sensor and collects the measurements.

The method involves several steps:

• The mobile platform navigates the field and generates real-time position and orientation data.
• The sensor takes soil conductivity measurements and synchronizes them with the position data.
• The measurements are then mapped and logged in real-time.
• Finally, the measurements are processed to calculate the soil moisture value.

Potential applications of this technology include:

• Precision agriculture: Farmers can use the soil moisture data to optimize irrigation and fertilizer application, leading to improved crop yield and resource efficiency.
• Environmental monitoring: The technology can be used to assess soil moisture levels in natural ecosystems, helping with land management and conservation efforts.

This technology solves the following problems:

• Accurate and efficient measurement of soil moisture: The mobile platform and sensor provide real-time data collection, eliminating the need for manual measurements and reducing labor costs.
• Spatial variability: By mapping and logging the measurements, the technology accounts for variations in soil moisture across the field, allowing for targeted interventions.

The benefits of this technology include:

• Improved crop yield: By optimizing irrigation and fertilizer application based on accurate soil moisture data, farmers can increase their productivity.
• Resource efficiency: Precise measurement and targeted interventions reduce water and fertilizer waste, leading to more sustainable agricultural practices.
• Time and labor savings: The automated data collection and processing streamline the soil moisture monitoring process, saving farmers time and reducing labor requirements.

Abstract

Apparatus and methods for determining soil moisture. An apparatus includes a mobile platform to traverse an agricultural field, a sensor physically coupled to the mobile platform, the sensor to make one or more soil apparent electrical conductivity measurements, and a control system mounted on the chassis and communicatively coupled to the sensor. A method includes navigating an agricultural field with a mobile platform, generating a real-time position and orientation for the mobile platform, performing one or more soil apparent electrical conductivity measurements from a sensor physically coupled to the mobile platform, synchronizing the one or more soil apparent electrical conductivity measurements with the real-time position, geospatial mapping and autonomously logging the one or more soil apparent electrical conductivity measurements, and processing each of the one or more soil apparent electrical conductivity measurements to generate a soil moisture value.

SCALE-, SHIFT-, AND ROTATION-INVARIANT DIFFRACTIVE OPTICAL NETWORKS (18249726)

Main Inventor

Aydogan Ozcan

Brief explanation

The abstract describes a method for creating an optical neural network that can process input object images or optical signals while being invariant to object transformations. The method involves training a software-based neural network model to perform specific optical functions for a multi-layer optical network. The training includes using input images or signals with random transformations and adjusting transmission/reflection coefficients for each layer until optimized coefficients are obtained. A physical embodiment of the network is then created with substrate layers that match the optimized coefficients.

• The method involves training a software-based neural network model to perform optical functions for an optical neural network.
• The training includes using input images or signals with random transformations.
• Transmission/reflection coefficients for each layer of the network are adjusted iteratively until optimized coefficients are obtained.
• A physical embodiment of the network is created with substrate layers matching the optimized coefficients.

Potential Applications

• Image recognition and processing
• Optical signal processing
• Pattern recognition
• Machine learning

Problems Solved

• Invariance to object transformations
• Efficient processing of input object images or optical signals
• Optimization of transmission/reflection coefficients for each layer

Benefits

• Improved accuracy and efficiency in processing object images or optical signals
• Ability to handle object transformations without affecting performance
• Physical embodiment of the network allows for practical implementation

Abstract

A method of forming an optical neural network for processing an input object image or optical signal that is invariant to object transformations includes training a software-based neural network model to perform one or more specific optical functions for a multi-layer optical network having physical features located in each of the layers of the optical neural network. The training includes feeding different input object images or optical signals that have random transformations or shifts and computing at least one optical output of optical transmission and/or reflection through the optical neural network using an optical wave propagation model and iteratively adjusting transmission/reflection coefficients for each layer until optimized transmission/reflection coefficients are obtained. A physical embodiment of the optical neural network is then made that has a plurality of substrate layers having physical features that match the optimized transmission/reflection coefficients obtained by the trained neural network model.

DEVICES AND METHODS EMPLOYING OPTICAL-BASED MACHINE LEARNING USING DIFFRACTIVE DEEP NEURAL NETWORKS (18316474)

Main Inventor

Aydogan Ozcan

Brief explanation

The abstract describes a patent application for an all-optical Diffractive Deep Neural Network (DNN) architecture. This architecture uses passive diffractive or reflective substrate layers to perform various functions or tasks. The application of this architecture was successfully demonstrated through the creation of 3D-printed DNNs that learned to implement handwritten classifications and lens function at the terahertz spectrum. The all-optical deep learning framework can perform complex functions and tasks at the speed of light, enabling applications in image analysis, feature detection, object classification, and new camera designs. It can also be used in conjunction with a digital neural network back-end.

• All-optical Diffractive Deep Neural Network (DNN) architecture
• Passive diffractive or reflective substrate layers are designed using deep learning
• 3D-printed DNNs successfully implement handwritten classifications and lens function
• Performs complex functions and tasks at the speed of light
• Applications in image analysis, feature detection, object classification, and camera designs
• Can be used with a digital neural network back-end

Potential Applications

• All-optical image analysis
• Feature detection
• Object classification
• New camera designs
• Optical components that can learn to perform unique tasks using DNNs

Problems Solved

• Enables all-optical implementation of complex functions and tasks
• Speeds up processing by performing tasks at the speed of light
• Provides a framework for designing optical components that can learn to perform specific tasks

Benefits

• Faster processing speed compared to computer-based neural networks
• All-optical implementation allows for real-time analysis and classification
• Enables the development of new camera designs and optical components

Abstract

An all-optical Diffractive Deep Neural Network (DNN) architecture learns to implement various functions or tasks after deep learning-based design of the passive diffractive or reflective substrate layers that work collectively to perform the desired function or task. This architecture was successfully confirmed experimentally by creating 3D-printed DNNs that learned to implement handwritten classifications and lens function at the terahertz spectrum. This all-optical deep learning framework can perform, at the speed of light, various complex functions and tasks that computer-based neural networks can implement, and will find applications in all-optical image analysis, feature detection and object classification, also enabling new camera designs and optical components that can learn to perform unique tasks using DNNs. In alternative embodiments, the all-optical DNN is used as a front-end in conjunction with a trained, digital neural network back-end.

Systems and Methods for Ground Truthing Remotely Sensed Data (18252169)

Main Inventor

Lorna KABACHNIK

Brief explanation

The patent application describes systems and methods for collecting tree census data, with improvements to tree modeling and accuracy in measuring tree crowns. It also discusses using this method to ground truth high-resolution satellite imagery, LiDAR, and other remotely sensed products and models. Additionally, it suggests applying this method to model and ground truth irregularly shaped phenomena like nebula, vapor plumes, volcanic eruptions, cloud cover, and sea cover on Earth or other planetary bodies. The technology can also improve modeling of remotely sensed physical phenomena from data collected by satellites, sensors, telescopes, and astrophotography systems.

• The patent application focuses on tree census collection and tree modeling.
• It proposes improvements to accurately measure tree crowns and dimensions.
• The method can be used to ground truth high-resolution satellite imagery, LiDAR, and other remotely sensed products and models.
• It suggests applying the method to model and ground truth irregularly shaped phenomena like nebula, vapor plumes, volcanic eruptions, cloud cover, and sea cover.
• The technology can improve modeling of remotely sensed physical phenomena from various data sources.

Potential Applications

The technology described in the patent application has potential applications in various fields, including:

• Environmental monitoring and conservation efforts
• Urban planning and management
• Forestry and agriculture management
• Climate change research and analysis
• Remote sensing data analysis and modeling

Problems Solved

The patent application addresses several problems in tree census collection and modeling, as well as in remote sensing data analysis. These problems include:

• Inaccurate measurement of tree crowns and dimensions
• Lack of ground truth data for high-resolution satellite imagery and other remotely sensed products
• Difficulty in modeling irregularly shaped phenomena
• Limited accuracy and resolution in modeling remotely sensed physical phenomena

Benefits

The technology described in the patent application offers several benefits, including:

• Improved accuracy in tree modeling and measurement of tree crowns
• Ground truth data for validating high-resolution satellite imagery and other remotely sensed products
• Enhanced modeling of irregularly shaped phenomena
• Improved accuracy and resolution in modeling remotely sensed physical phenomena
• Potential for better environmental monitoring, urban planning, forestry management, and climate change research.

Abstract

Systems and methods for tree census collection are provided. Many embodiments provide improvements to tree modeling, including dimensions of tree crowns, which provides greater accuracy in tree modeling. Furthermore, the improvements to tree modeling provide in-situ datasets to ground truth high resolution satellite imagery, LiDAR, and other remotely sensed products and models. The method may also be used to model and ground truth other remotely sensed phenomena having irregular shapes, such as nebula, vapor plumes, volcanic eruptions, cloud cover, sea cover, on Earth, other planetary bodies, or elsewhere in space, and for improved modeling of remotely sensed physical phenomena from data collected from satellites, embedded sensors, telescopes and other astrophotography systems.

OPTIMAL MULTI-ELECTRODE TRANSCUTANEOUS STIMULATION WITH HIGH FOCALITY AND INTENSITY (18332091)

Main Inventor

Ying Li

Brief explanation

Methods, apparatus, and systems have been developed to optimize transcutaneous stimulation for precise and focused stimulation of target tissues such as the spinal cord, brain, or other internal organs. These techniques involve the use of a realistic 3D model generated from CT/MRI images and an optimization algorithm.

• The patent application describes a method for designing optimal parameters for transcutaneous stimulation.
• The method includes generating a 3D model from CT/MRI images of the target tissue.
• An optimization algorithm is used to determine the optimal parameters for stimulation.
• The algorithm allows for stimulation of any target location with any orientation, ensuring high precision.

Potential applications of this technology:

• Medical treatments involving transcutaneous stimulation of target tissues such as the spinal cord, brain, or internal organs.
• Rehabilitation therapies for patients with neurological disorders or injuries.
• Research studies investigating the effects of transcutaneous stimulation on specific target tissues.

Problems solved by this technology:

• Precise and focused stimulation of target tissues can be challenging to achieve using traditional methods.
• Designing optimal parameters for transcutaneous stimulation can be time-consuming and complex.
• The use of a realistic 3D model and an optimization algorithm helps overcome these challenges and enables more accurate and efficient stimulation.

Benefits of this technology:

• Improved precision in transcutaneous stimulation, leading to better targeting of specific tissues.
• Time and cost savings in the design of optimal stimulation parameters.
• Enhanced effectiveness of medical treatments and rehabilitation therapies.

Abstract

Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.

METHOD OF TRANSFERRING A PATTERN TO AN EPITAXIAL LAYER OF A LIGHT EMITTING DEVICE (18248740)

Main Inventor

Srinivas Grandrothula

Brief explanation

The abstract of the patent application describes a technology for integrating light extraction or guiding structures into light emitting devices. These structures are created using a lateral epitaxial growth technique that transfers a pattern from a growth restrict mask and/or host substrate to the epitaxial layers.

• Light emitting devices with integrated light extraction or guiding structures
• Structures are fabricated using a lateral epitaxial growth technique
• Pattern is transferred from a growth restrict mask and/or host substrate to the epitaxial layers

Potential Applications

This technology has potential applications in various fields, including:

• Lighting industry
• Display technology
• Optical communication
• Photovoltaics

Problems Solved

The technology addresses several problems in the field of light emitting devices, such as:

• Low light extraction efficiency
• Inefficient light guiding
• Complex fabrication processes

Benefits

The use of this technology offers several benefits, including:

• Improved light extraction efficiency
• Enhanced light guiding capabilities
• Simplified fabrication processes
• Cost-effective production methods

Abstract

Light emitting devices having light extraction or guiding structures integrated in their epitaxial layers, wherein the light extraction and guiding structures are fabricated using a lateral epitaxial growth technique that transfers a pattern from a growth restrict mask and/or host substrate to the epitaxial layers.

STABILIZED ELECTROLYTES FOR LOW-TEMPERATURE BATTERIES (18031857)

Main Inventor

Zheng CHEN

Brief explanation

==Abstract==

Lithium batteries (LBs) are made using an electrolyte that contains a lithium salt in a primary solvent called ester, along with a small amount (5% to 30%) of ethylene carbonate (EC). These batteries have excellent electrochemical stability and ionic conductivity, especially at low temperatures.

Patent/Innovation Explanation

• Lithium batteries are created using a specific electrolyte composition.
• The electrolyte includes a lithium salt and a primary solvent called ester.
• A small percentage (5% to 30%) of ethylene carbonate (EC) is also added to the electrolyte.
• This specific electrolyte composition results in lithium batteries with high electrochemical stability.
• The batteries also exhibit excellent ionic conductivity, particularly at low temperatures.

Potential Applications

• Lithium batteries with improved electrochemical stability and ionic conductivity can be used in various electronic devices.
• These batteries may find applications in smartphones, laptops, tablets, and other portable electronic devices.
• They can also be used in electric vehicles, where high performance and reliability are crucial.
• The improved low-temperature performance makes them suitable for use in cold climates or extreme environments.

Problems Solved

• The electrolyte composition addresses the issue of electrochemical stability in lithium batteries.
• The addition of ethylene carbonate helps improve the ionic conductivity of the batteries.
• The technology solves the problem of reduced battery performance at low temperatures.

Benefits

• Lithium batteries with high electrochemical stability offer improved safety and longer lifespan.
• The enhanced ionic conductivity ensures better battery performance and faster charging.
• The batteries' ability to maintain performance at low temperatures makes them more reliable in various conditions.
• The technology provides a solution for the limitations of conventional lithium batteries.

Abstract

Lithium batteries (LBs) are formed using an electrolyte including a lithium salt in an ester primary solvent with a low percentage of about 5% to about 30% of an ethylene carbonate (EC). The batteries exhibit high electrochemical stability and ionic conductivity at low temperatures.