18249716. HIGH-TRANSCONDUCTANCE ORGANIC ELECTROCHEMICAL TRANSISTOR (OECT)-BASED SENSORS AND METHODS OF USE simplified abstract (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)

HIGH-TRANSCONDUCTANCE ORGANIC ELECTROCHEMICAL TRANSISTOR (OECT)-BASED SENSORS AND METHODS OF USE

Organization Name

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor(s)

Alireza Khademhosseini of Los Angeles CA (US)

Shiming Zhang of Los Angeles CA (US)

HIGH-TRANSCONDUCTANCE ORGANIC ELECTROCHEMICAL TRANSISTOR (OECT)-BASED SENSORS AND METHODS OF USE - A simplified explanation of the abstract

This abstract first appeared for US patent application 18249716 titled 'HIGH-TRANSCONDUCTANCE ORGANIC ELECTROCHEMICAL TRANSISTOR (OECT)-BASED SENSORS AND METHODS OF USE

Simplified Explanation

The patent application describes a sensor device that uses a circular-shaped gate electrode and source and drain electrodes with a curvy and wavy pattern. This design allows for the creation of high-transconductance organic electrochemical transistors (OECTs) for multiplexed biosensors.

• The sensor device uses a circular-shaped gate electrode and source and drain electrodes with a curvy and wavy pattern.
• The arrangement of the source and drain electrodes around the gate electrode enables the creation of high-transconductance OECTs.
• This design allows for the development of multiplexed OECT-based biosensors for high-throughput screening of multiple biomarkers/biomolecules.
• The platform can be used for point-of-care applications, wearable biosensing, and minimally-invasive biosensing with microneedles or a catheter/probe as a carrier for the high-transconductance OECTs.

Potential Applications

The technology described in this patent application has several potential applications:

• Point-of-care applications: The high-transconductance OECT-based biosensors can be used for rapid and on-site detection of biomarkers, enabling quick diagnosis and treatment decisions.
• Wearable biosensing: The sensor device can be integrated into wearable devices, such as smartwatches or fitness trackers, to continuously monitor biomarkers and provide real-time health information.
• Minimally-invasive biosensing: The high-transconductance OECTs can be incorporated into microneedles or catheters/probes for minimally-invasive monitoring of biomarkers, reducing the need for invasive procedures.

Problems Solved

The technology described in this patent application solves several problems:

• High-transconductance OECTs: The curvy and wavy pattern of the source and drain electrodes allows for the creation of high-transconductance OECTs, which improves the sensitivity and accuracy of the biosensors.
• Multiplexed biosensing: The arrangement of the electrodes enables the development of multiplexed OECT-based biosensors, allowing for the simultaneous detection of multiple biomarkers or biomolecules.
• Versatile applications: The platform can be used for various applications, including point-of-care, wearable, and minimally-invasive biosensing, providing flexibility and convenience in different healthcare settings.

Benefits

The technology described in this patent application offers several benefits:

• Improved sensitivity and accuracy: The high-transconductance OECTs provide enhanced sensitivity and accuracy in detecting biomarkers, enabling early disease detection and personalized medicine.
• High-throughput screening: The multiplexed OECT-based biosensors allow for high-throughput screening of multiple biomarkers or biomolecules, increasing efficiency and reducing time and cost.
• Versatile and flexible: The platform can be used in different healthcare settings, including point-of-care, wearable, and minimally-invasive applications, providing versatility and flexibility in monitoring biomarkers.

Original Abstract Submitted

An organic electrochemical transistor (OECT)-based sensor device is disclosed that uses circular-shaped gate electrode and source and drain electrodes that at least partially surround the gate electrode and have an undulating pattern that is generally described as curvy and wavy (CW). The arrangement of the source and drain electrodes around the gate electrode provides the ability to obtain high-transconductance OECT (HT-OECT). With the HT-OECT sensor design, multiplexed OECT-based biosensors can be created for high-throughput screening applications of multiple biomarkers/biomolecules. This platform can be used for point-of-care applications, wearable biosensing, and minimally-invasive biosensing with microneedles or a catheter/probe as a carrier for HT-OECT(s).