18332430. ASSAYS FOR DETECTION OF ACUTE LYME DISEASE simplified abstract (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)

ASSAYS FOR DETECTION OF ACUTE LYME DISEASE

Organization Name

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor(s)

Charles Y. Chiu of San Francisco CA (US)

Jerome Bouquet of San Francisco CA (US)

Mark J. Soloski of Baltimore MD (US)

John N. Aucott of Lutherville MD (US)

ASSAYS FOR DETECTION OF ACUTE LYME DISEASE - A simplified explanation of the abstract

This abstract first appeared for US patent application 18332430 titled 'ASSAYS FOR DETECTION OF ACUTE LYME DISEASE

Simplified Explanation

The patent application is about a method for determining whether a human subject has acute Lyme disease by analyzing the gene expression of cells in a blood sample.

• The method involves measuring the gene expression of cells in a blood sample obtained from a mammalian subject suspected of having a tick-borne disease.
• Specifically, the method focuses on transcriptome profiling of peripheral blood mononuclear cells.
• The goal is to determine whether the subject has acute Lyme disease based on the gene expression patterns observed in the blood sample.

Potential Applications

This technology has potential applications in the field of diagnosing tick-borne diseases, specifically acute Lyme disease.

• Medical diagnosis: The method can be used by healthcare professionals to accurately diagnose acute Lyme disease in human subjects.
• Treatment planning: The gene expression analysis can provide valuable information for developing personalized treatment plans for patients with acute Lyme disease.
• Research: The method can be used in research studies to better understand the gene expression patterns associated with tick-borne diseases.

Problems Solved

This technology addresses several problems related to the diagnosis of acute Lyme disease.

• Early detection: The method allows for the early detection of acute Lyme disease, enabling prompt treatment and potentially preventing the progression of the disease.
• Accuracy: By analyzing the gene expression patterns, the method provides a more accurate diagnosis compared to traditional diagnostic methods, which may have limitations in sensitivity and specificity.
• Non-invasive: The method utilizes a blood sample, which is a non-invasive and easily accessible specimen, making it convenient for patients and healthcare providers.

Benefits

The use of gene expression analysis for diagnosing acute Lyme disease offers several benefits.

• Improved accuracy: By analyzing gene expression patterns, the method provides a more accurate diagnosis, reducing the risk of misdiagnosis and ensuring appropriate treatment.
• Early intervention: Early detection of acute Lyme disease allows for timely intervention, potentially preventing the development of severe symptoms and complications.
• Personalized treatment: The gene expression analysis can provide insights into the specific molecular mechanisms involved in the disease, enabling personalized treatment plans tailored to individual patients.

Original Abstract Submitted

The present disclosure relates to measuring gene expression of cells of a blood sample obtained from a mammalian subject suspected of having a tick-borne disease. In particular, the present disclosure provides tools for determining whether a human subject has acute Lyme disease by transcriptome profiling a peripheral blood mononuclear cell sample from the subject.