US Patent Application 18448674. Methods and Culture Substrates for Controlled Induction of Biomimetic Neural Tissues Comprising Singular Rosette Structures simplified abstract
Methods and Culture Substrates for Controlled Induction of Biomimetic Neural Tissues Comprising Singular Rosette Structures
Organization Name
Wisconsin Alumni Research Foundation
Inventor(s)
Randolph Scott Ashton of Madison WI (US)
Gavin T. Knight of Coral Springs FL (US)
Methods and Culture Substrates for Controlled Induction of Biomimetic Neural Tissues Comprising Singular Rosette Structures - A simplified explanation of the abstract
This abstract first appeared for US patent application 18448674 titled 'Methods and Culture Substrates for Controlled Induction of Biomimetic Neural Tissues Comprising Singular Rosette Structures
Simplified Explanation
- The patent application describes methods, compositions, and kits for directing the differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues. - The goal is to create neural tissues that resemble the developing human neural tube, specifically focusing on the formation of rosette structures. - The patent application also mentions the creation of engineered neural tissue preparations that contain biomimetic neural tissues with regional neural progenitor phenotypes.
Original Abstract Submitted
Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising one or more rosette structures. Preferably, the methods provided herein direct differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues comprising a singular neural rosette structure that is comparable to at least a portion of the developing human neural tube. Also described are engineered neural tissue preparations comprising biomimetic neural tissues comprising a singular rosette structure having regional neural progenitor phenotypes.
