US Patent Application 18323912. MICROBES WITH REDUCED ADHESION CHARACTERISTICS simplified abstract
Contents
MICROBES WITH REDUCED ADHESION CHARACTERISTICS
Organization Name
Wisconsin Alumni Research Foundation
Inventor(s)
Jan Peter Van Pijkeren of Madison WI (US)
Laura Alexander of Fitchburg WI (US)
MICROBES WITH REDUCED ADHESION CHARACTERISTICS - A simplified explanation of the abstract
This abstract first appeared for US patent application 18323912 titled 'MICROBES WITH REDUCED ADHESION CHARACTERISTICS
Simplified Explanation
- The patent application is about recombinant microorganisms and their use in delivering biologics to the gastrointestinal tract. - The recombinant microorganisms have been modified to reduce the expression and/or activity of certain proteins that are involved in adhesion. - These modifications result in reduced adhesion characteristics compared to non-modified microbes. - The recombinant microorganisms also contain a recombinant gene that allows them to express a biologic. - The main purpose of the invention is to use these modified microorganisms as delivery vehicles for biologics to specific sites in the body, such as the gastrointestinal tract.
Original Abstract Submitted
Recombinant microorganisms and methods of using same. The recombinant microorganisms include one or more modifications that reduce the expression and/or activity of a sortase, a sortase-dependent protein, a fibronectin-binding protein, an autolysin, a surface-layer protein, an aggregation-promoting factor, and/or a collagen-binding protein. The modifications can reduce the adhesion characteristics with respect to the non-modified microbes. The recombinant microorganisms can further include a recombinant gene configured to express a biologic. The recombinant microorganisms can be used as delivery vehicles to deliver the biologics to sites such as the gastrointestinal tract.
