US Patent Application 18201887. Use of Non-Invasive Sensory Systems to Titrate Cranial Nerve Stimulation to Enhance Brain Clearance Closed-Loop simplified abstract

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Use of Non-Invasive Sensory Systems to Titrate Cranial Nerve Stimulation to Enhance Brain Clearance Closed-Loop

Organization Name

Wisconsin Alumni Research Foundation

Inventor(s)

Kip Ludwig of Middleton WI (US)

Nishant Verma of Madison WI (US)

Justin Williams of Cambridge WI (US)

Use of Non-Invasive Sensory Systems to Titrate Cranial Nerve Stimulation to Enhance Brain Clearance Closed-Loop - A simplified explanation of the abstract

This abstract first appeared for US patent application 18201887 titled 'Use of Non-Invasive Sensory Systems to Titrate Cranial Nerve Stimulation to Enhance Brain Clearance Closed-Loop

Simplified Explanation

- The patent application is about real-time sensing of cerebrospinal fluid (CSF) clearance. - This sensing can help optimize electrode target engagement of peripheral cranial nerves and detect changes in the connected nerve truck and brain. - The CSF clearance data can be used in "open loop" systems to inform operator-controlled programming or sent directly to the stimulator for programming adjustments in a "closed loop" manner. - The innovation aims to improve the effectiveness and precision of electrode targeting and programming in cranial nerve stimulation.


Original Abstract Submitted

Real-time sensing of cerebrospinal fluid (CSF) clearance can be used to optimize electrode target engagement of the peripheral cranial nerves and detect associated changes within the connected nerve truck and brain. This CSF clearance data may be used in “open loop” systems to inform operator-controlled programming or sent directly to the stimulator itself to titrate programming “closed loop” on the device.