US Patent Application 18176021. CIRCULAR RNAS AND THEIR USE IN IMMUNOMODULATION simplified abstract
Contents
CIRCULAR RNAS AND THEIR USE IN IMMUNOMODULATION
Organization Name
The Board of Trustees of the Leland Stanford Junior University
Inventor(s)
Howard Y. Chang of Stanford CA (US)
Ye Grace Chen of Stanford CA (US)
Bali Pulendran of Stanford CA (US)
Sudhir Kasturi of Atlanta GA (US)
CIRCULAR RNAS AND THEIR USE IN IMMUNOMODULATION - A simplified explanation of the abstract
This abstract first appeared for US patent application 18176021 titled 'CIRCULAR RNAS AND THEIR USE IN IMMUNOMODULATION
Simplified Explanation
- The patent application is about compositions and methods for modulating an innate immune response using circular RNAs. - Circular RNAs are modified forms of RNA that can be used to stimulate or prevent immune responses. - The methods involve circularizing RNA molecules, either by adding exogenous introns to stimulate an immune response or by using endogenous introns to prevent immune recognition of foreign RNA. - The innovation lies in the use of circular RNAs to modulate the innate immune response, which can have various applications in the field of immunology and therapeutics.
Original Abstract Submitted
Compositions and methods of modulating an innate immune response with circular RNAs are disclosed. In particular, the disclosure relates to methods for modifying an RNA by circularization and the use of circular RNAs generated with exogenous introns to stimulate an innate immune response or circular RNAs generated with endogenous introns to prevent immune recognition of foreign RNA.
