US Patent Application 18029619. METHODS AND COMPOSITIONS FOR THE TREATMENT OF IMPLANT ASSOCIATED COMPLICATIONS simplified abstract

From WikiPatents
Jump to navigation Jump to search

METHODS AND COMPOSITIONS FOR THE TREATMENT OF IMPLANT ASSOCIATED COMPLICATIONS

Organization Name

The Board of Trustees of the Leland Stanford Junior University

Inventor(s)

Geoffrey C. Gurtner of Portola Valley CA (US)

Jagannath Padmanabhan of Redwood City CA (US)

METHODS AND COMPOSITIONS FOR THE TREATMENT OF IMPLANT ASSOCIATED COMPLICATIONS - A simplified explanation of the abstract

This abstract first appeared for US patent application 18029619 titled 'METHODS AND COMPOSITIONS FOR THE TREATMENT OF IMPLANT ASSOCIATED COMPLICATIONS

Simplified Explanation

The patent application is about preventing and treating complications associated with implants, such as foreign body response (FBR).

  • The invention focuses on inhibiting mechanotransduction, which is the process by which mechanical stress at the implant-tissue interface triggers an inflammatory response.
  • The sustained inflammatory response caused by high mechanical stress is a major factor in implant failure and complications.
  • The patent application describes apparatuses, devices, and compositions that contain inhibitors of mechanotransduction.
  • These inventions aim to prevent or reduce unwanted fibrosis, inflammation, or cancer that can occur after implantation of a biomedical implant.
  • The biomedical device described in the patent application includes a composition containing a mechanotransduction inhibitor to prevent, inhibit, or treat implant-associated complications.


Original Abstract Submitted

The present invention relates to the prevention and treatment of implant associated complications; e.g. foreign body response (FBR). High mechanical stress at the implant-tissue interface activates a sustained inflammatory response, which is primarily responsible for implant associated complications and implant failure. In particular, described herein are apparatuses, devices, and compositions containing inhibitors of mechanotransduction, and methods of making and using such apparatuses, devices and compositions. These apparatuses, devices, compositions, and methods are useful for preventing or reducing unwanted fibrosis, inflammation or cancer that result from implantation of a biomedical implant in an individual. One aspect of the invention provides a biomedical device including an effective amount of a composition containing a mechanotransduction inhibitor for preventing, inhibiting or treating implant associated complications.

Retrieved from "http://wikipatents.org/index.php?title=US_Patent_Application_18029619._METHODS_AND_COMPOSITIONS_FOR_THE_TREATMENT_OF_IMPLANT_ASSOCIATED_COMPLICATIONS_simplified_abstract&oldid=15115"