18018660. COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS (MASSACHUSETTS INSTITUTE OF TECHNOLOGY)

COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS

Organization Name

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor(s)

Patrick S. Doyle of Sudbury MA US

Jeremy Schieferstein of Medford MA US

Paul Reichert of Montville NJ US

Chakravarthy Narasimhan of Scotch Plains NJ US

Amir Erfani-khaneghahi of Somerville MA US

COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS

This abstract first appeared for US patent application 18018660 titled 'COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS

Original Abstract Submitted

Compositions including solid forms of polypeptides such as crystalline antibodies, and related methods, are generally described. The compositions may include carriers such as hydrogels that at least partially encapsulate the solid form of the polypeptides (e.g., crystals, amorphous solids). Encapsulation with certain of the materials described may result in compositions containing relatively high loadings of polypeptides while in some instances retaining structural and functional properties of the polypeptides useful for certain types of administration to subjects (e.g., for prophylactic or therapeutic applications). In some instances, compositions having relatively low dynamic viscosities while having relatively high polypeptide loadings are provided.