18018660. COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS (MASSACHUSETTS INSTITUTE OF TECHNOLOGY)
COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS
Organization Name
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor(s)
Patrick S. Doyle of Sudbury MA US
Jeremy Schieferstein of Medford MA US
Paul Reichert of Montville NJ US
Chakravarthy Narasimhan of Scotch Plains NJ US
Amir Erfani-khaneghahi of Somerville MA US
COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS
This abstract first appeared for US patent application 18018660 titled 'COMPOSITIONS INCLUDING SOLID FORMS OF POLYPEPTIDES AND RELATED METHODS
Original Abstract Submitted
Compositions including solid forms of polypeptides such as crystalline antibodies, and related methods, are generally described. The compositions may include carriers such as hydrogels that at least partially encapsulate the solid form of the polypeptides (e.g., crystals, amorphous solids). Encapsulation with certain of the materials described may result in compositions containing relatively high loadings of polypeptides while in some instances retaining structural and functional properties of the polypeptides useful for certain types of administration to subjects (e.g., for prophylactic or therapeutic applications). In some instances, compositions having relatively low dynamic viscosities while having relatively high polypeptide loadings are provided.
