View source for Lemba BV (20250115909). COMPOUNDS FOR INHIBITING AMANZI

=COMPOUNDS FOR INHIBITING AMANZI=


==Organization Name==

[[:Category:Lemba BV|Lemba BV]]


[[Category:Lemba BV]]

==Inventor(s)==

[[:Category:Ezio Fok of Nijmegen NL|Ezio Fok of Nijmegen NL]][[Category:Ezio Fok of Nijmegen NL]]

[[:Category:Stephanie Berry of Scarsdale NY US|Stephanie Berry of Scarsdale NY US]][[Category:Stephanie Berry of Scarsdale NY US]]

[[:Category:Makiri Kawasaki of Tokyo JP|Makiri Kawasaki of Tokyo JP]][[Category:Makiri Kawasaki of Tokyo JP]]

==COMPOUNDS FOR INHIBITING AMANZI==


This abstract first appeared for US patent application 20250115909 titled 'COMPOUNDS FOR INHIBITING AMANZI

==Original Abstract Submitted==

the inventions relate to an aso (antisense oligonucleotide) compound that can inhibit amanzi transcriptional activity. more specifically, the disclosed aso comprises a gapmer type of aso comprising from about 14 to about 25 nucleotide bases; (a) a 3′ wing region (3′ to 5′) having from 3 to 7 chemically modified rna bases; (b) a gap region having from at least 8 dna bases to no more than 19 dna bases; and (c) a 5′ wing region (3′ to 5′) having from 3 to 7 chemically modified rna bases. preferably, the gapmer is substantially complementary to a region on amanzi (seq id no. 1). more preferably, the gapmer is substantially complementary to a 14-25 base region on amanzi.



[[Category:C12N15/113]]
[[Category:CPC_C12N15/113]]