Lemba BV (20250115909). COMPOUNDS FOR INHIBITING AMANZI
COMPOUNDS FOR INHIBITING AMANZI
Organization Name
Inventor(s)
Stephanie Berry of Scarsdale NY US
COMPOUNDS FOR INHIBITING AMANZI
This abstract first appeared for US patent application 20250115909 titled 'COMPOUNDS FOR INHIBITING AMANZI
Original Abstract Submitted
the inventions relate to an aso (antisense oligonucleotide) compound that can inhibit amanzi transcriptional activity. more specifically, the disclosed aso comprises a gapmer type of aso comprising from about 14 to about 25 nucleotide bases; (a) a 3′ wing region (3′ to 5′) having from 3 to 7 chemically modified rna bases; (b) a gap region having from at least 8 dna bases to no more than 19 dna bases; and (c) a 5′ wing region (3′ to 5′) having from 3 to 7 chemically modified rna bases. preferably, the gapmer is substantially complementary to a region on amanzi (seq id no. 1). more preferably, the gapmer is substantially complementary to a 14-25 base region on amanzi.