View source for 20250205225. Methods Potentiati (University of Cincinnati)

= METHODS OF POTENTIATING TEMOZOLOMIDE ACTIVITY AGAINST GLIOBLASTOMA CELLS =

'''Abstract''':
provided herein is a method of potentiating a cytotoxic effect of temozolomide against glioblastoma cells in a subject in need thereof, the method including administering to the subject a combination of: a therapeutically effective amount of temozolomide; and a non-cytotoxic amount of letrozole, wherein the letrozole potentiates the cytotoxic effect of the temozolomide against the glioblastoma cells. also provided is a method of restoring sensitivity of temozolomide-resistant glioblastoma cells to temozolomide, including contacting the glioblastoma cells with a non-cytotoxic amount of letrozole and method of treating glioblastoma.

'''Inventor(s)''': [[:Category:Pankaj B. Desai of Cincinnati OH US|Pankaj B. Desai]], [[:Category:Aniruddha S. Karve of Cincinnati OH US|Aniruddha S. Karve]], [[:Category:Janki Mihir Desai of Lawrenceburg IN US|Janki Mihir Desai]], [[:Category:Timothy Phoenix of Blue Ash OH US|Timothy Phoenix]], [[:Category:Nimita Dave of Roslindale MA US|Nimita Dave]], [[:Category:Gary Gudelsky of Cincinnati OH US|Gary Gudelsky]]

'''CPC Classification''': [[:Category:CPC_A61K31/495|A61K31/495]] (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES  (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))


[[Category:Patent Applications]]
[[Category:University of Cincinnati]]
[[Category:CPC_A61K31/495]]
[[Category:Pankaj B. Desai of Cincinnati OH US]]
[[Category:Aniruddha S. Karve of Cincinnati OH US]]
[[Category:Janki Mihir Desai of Lawrenceburg IN US]]
[[Category:Timothy Phoenix of Blue Ash OH US]]
[[Category:Nimita Dave of Roslindale MA US]]
[[Category:Gary Gudelsky of Cincinnati OH US]]

[https://wikipatents.org/index.php?search=20250205225+rejection&title=Special%3ASearch&wprov=acrw1_-1 Search for rejections for patent application number 20250205225]


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