METHODS OF POTENTIATING TEMOZOLOMIDE ACTIVITY AGAINST GLIOBLASTOMA CELLS

Abstract: provided herein is a method of potentiating a cytotoxic effect of temozolomide against glioblastoma cells in a subject in need thereof, the method including administering to the subject a combination of: a therapeutically effective amount of temozolomide; and a non-cytotoxic amount of letrozole, wherein the letrozole potentiates the cytotoxic effect of the temozolomide against the glioblastoma cells. also provided is a method of restoring sensitivity of temozolomide-resistant glioblastoma cells to temozolomide, including contacting the glioblastoma cells with a non-cytotoxic amount of letrozole and method of treating glioblastoma.

Inventor(s): Pankaj B. Desai, Aniruddha S. Karve, Janki Mihir Desai, Timothy Phoenix, Nimita Dave, Gary Gudelsky

CPC Classification: A61K31/495 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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