View source for 20250186597. Targeted Immune Ac (BRIGHT PEAK THERAPEUTICS AG)

= TARGETED IMMUNE ACTIVATION WITH IL-18 IMMUNOCYTOKINES =

'''Abstract''':
the present disclosure relates to modified immunocytokine compositions comprising antibodies or antigen binding fragments specific for immune cell antigens (e.g., pd-1) and il-18 polypeptides which are able to selectively stimulate the immune system at desired locations, such as within a tumor microenvironment. such immunocytokines are in some instances useful for the expansion of cd8 t cells in a subject, preferably in a tumor or tumor microenvironment of the subject. also provided herein are methods of treatment with and methods of manufacture of immunocytokine compositions.

'''Inventor(s)''': [[:Category:Bertolt KREFT of Kleinmachnow  DE|Bertolt KREFT]], [[:Category:Vijaya Raghavan PATTABIRAMAN of Volketswil  CH|Vijaya Raghavan PATTABIRAMAN]], [[:Category:Jean-Philippe CARRALOT of Saint-Louis  FR|Jean-Philippe CARRALOT]], [[:Category:Kea MARTIN of Istein  DE|Kea MARTIN]], [[:Category:Arnaud GOEPFERT of Sierentz  FR|Arnaud GOEPFERT]]

'''CPC Classification''': [[:Category:CPC_A61K47/62|A61K47/62]] (the modifying agent being a protein, peptide or polyamino acid)


[[Category:Patent Applications]]
[[Category:BRIGHT PEAK THERAPEUTICS AG]]
[[Category:CPC_A61K47/62]]
[[Category:Bertolt KREFT of Kleinmachnow  DE]]
[[Category:Vijaya Raghavan PATTABIRAMAN of Volketswil  CH]]
[[Category:Jean-Philippe CARRALOT of Saint-Louis  FR]]
[[Category:Kea MARTIN of Istein  DE]]
[[Category:Arnaud GOEPFERT of Sierentz  FR]]

[https://wikipatents.org/index.php?search=20250186597+rejection&title=Special%3ASearch&wprov=acrw1_-1 Search for rejections for patent application number 20250186597]


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