TARGETED IMMUNE ACTIVATION WITH IL-18 IMMUNOCYTOKINES

Abstract: the present disclosure relates to modified immunocytokine compositions comprising antibodies or antigen binding fragments specific for immune cell antigens (e.g., pd-1) and il-18 polypeptides which are able to selectively stimulate the immune system at desired locations, such as within a tumor microenvironment. such immunocytokines are in some instances useful for the expansion of cd8 t cells in a subject, preferably in a tumor or tumor microenvironment of the subject. also provided herein are methods of treatment with and methods of manufacture of immunocytokine compositions.

Inventor(s): Bertolt KREFT, Vijaya Raghavan PATTABIRAMAN, Jean-Philippe CARRALOT, Kea MARTIN, Arnaud GOEPFERT

CPC Classification: A61K47/62 (the modifying agent being a protein, peptide or polyamino acid)

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