View source for 20240033402. METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE simplified abstract (Spiber Technologies AB)

=METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE=


==Organization Name==

[[:Category:Spiber Technologies AB|Spiber Technologies AB]]


[[Category:Spiber Technologies AB]]

==Inventor(s)==

[[:Category:Mona Widhe of Uppsala (SE)|Mona Widhe of Uppsala (SE)]][[Category:Mona Widhe of Uppsala (SE)]]

[[:Category:My Hedhammar of Stockholm (SE)|My Hedhammar of Stockholm (SE)]][[Category:My Hedhammar of Stockholm (SE)]]

[[:Category:Gemma Mestres of Stockholm (SE)|Gemma Mestres of Stockholm (SE)]][[Category:Gemma Mestres of Stockholm (SE)]]

[[:Category:Anna Diez-escudero of Stockholm (SE)|Anna Diez-escudero of Stockholm (SE)]][[Category:Anna Diez-escudero of Stockholm (SE)]]

==METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE - A simplified explanation of the abstract==


This abstract first appeared for US patent application 20240033402 titled 'METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE

==Simplified Explanation==

The abstract describes a method for producing macroporous scaffolds for bone generation. The method involves foaming a liquid phase containing a non-denatured silk protein and blending a mineral phase consisting of α-tricalcium phosphate (α-TCP) with hydroxyapatite (HA) into the foamed liquid phase. This forms a macroporous paste, which is then stabilized into a desired shape and mineralized into a macroporous calcium-deficient hydroxyapatite (CDHA)-based scaffold.

* The method involves foaming a liquid phase containing a non-denatured silk protein.
* A mineral phase consisting of α-tricalcium phosphate (α-TCP) with hydroxyapatite (HA) is blended into the foamed liquid phase.
* This forms a macroporous paste.
* The macroporous paste is stabilized into a desired shape.
* The stabilized, shaped porous paste is mineralized into a macroporous calcium-deficient hydroxyapatite (CDHA)-based scaffold.

Potential applications of this technology:
* Bone generation and tissue engineering.
* Regenerative medicine and orthopedic surgeries.
* Dental implants and bone grafts.

Problems solved by this technology:
* Lack of suitable scaffolds for bone generation.
* Limited availability of macroporous scaffolds.
* Difficulty in stabilizing and shaping macroporous pastes.

Benefits of this technology:
* Provides a method for producing macroporous scaffolds for bone generation.
* Allows for the incorporation of α-tricalcium phosphate and hydroxyapatite into the scaffold.
* Offers a mineralized macroporous scaffold with a desired shape and stability.


==Original Abstract Submitted==

a method for producing macroporous scaffolds which are useful in bone generation is provided. a liquid phase which is an aqueous solution of a non-denatured silk protein is subjected to mechanical foaming. a mineral phase comprising �-tricalcium phosphate (�-tcp) with hydroxyapatite (ha) is blended into the foamed liquid phase during continued mechanical foaming, thereby forming a macroporous paste. the macroporous paste is stabilized into a desired shape. the stabilized, shaped porous paste is mineralized into a macroporous calcium-deficient hydroxyapatite (cdha)-based scaffold.



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