20240033402. METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE simplified abstract (Spiber Technologies AB)
METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE
Organization Name
Inventor(s)
My Hedhammar of Stockholm (SE)
Gemma Mestres of Stockholm (SE)
Anna Diez-escudero of Stockholm (SE)
METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240033402 titled 'METHOD FOR PRODUCING MACROPOROUS SCAFFOLDS COMPOSED OF SILK AND CALCIUM PHOSPHATE
Simplified Explanation
The abstract describes a method for producing macroporous scaffolds for bone generation. The method involves foaming a liquid phase containing a non-denatured silk protein and blending a mineral phase consisting of α-tricalcium phosphate (α-TCP) with hydroxyapatite (HA) into the foamed liquid phase. This forms a macroporous paste, which is then stabilized into a desired shape and mineralized into a macroporous calcium-deficient hydroxyapatite (CDHA)-based scaffold.
- The method involves foaming a liquid phase containing a non-denatured silk protein.
- A mineral phase consisting of α-tricalcium phosphate (α-TCP) with hydroxyapatite (HA) is blended into the foamed liquid phase.
- This forms a macroporous paste.
- The macroporous paste is stabilized into a desired shape.
- The stabilized, shaped porous paste is mineralized into a macroporous calcium-deficient hydroxyapatite (CDHA)-based scaffold.
Potential applications of this technology:
- Bone generation and tissue engineering.
- Regenerative medicine and orthopedic surgeries.
- Dental implants and bone grafts.
Problems solved by this technology:
- Lack of suitable scaffolds for bone generation.
- Limited availability of macroporous scaffolds.
- Difficulty in stabilizing and shaping macroporous pastes.
Benefits of this technology:
- Provides a method for producing macroporous scaffolds for bone generation.
- Allows for the incorporation of α-tricalcium phosphate and hydroxyapatite into the scaffold.
- Offers a mineralized macroporous scaffold with a desired shape and stability.
Original Abstract Submitted
a method for producing macroporous scaffolds which are useful in bone generation is provided. a liquid phase which is an aqueous solution of a non-denatured silk protein is subjected to mechanical foaming. a mineral phase comprising �-tricalcium phosphate (�-tcp) with hydroxyapatite (ha) is blended into the foamed liquid phase during continued mechanical foaming, thereby forming a macroporous paste. the macroporous paste is stabilized into a desired shape. the stabilized, shaped porous paste is mineralized into a macroporous calcium-deficient hydroxyapatite (cdha)-based scaffold.
