WUHAN HESHENG TECHNOLOGY CO., LTD. (20250129357). VALENCENE SYNTHASE MUTANT AND VALENCENE HIGH-YIELD STRAIN
VALENCENE SYNTHASE MUTANT AND VALENCENE HIGH-YIELD STRAIN
Organization Name
WUHAN HESHENG TECHNOLOGY CO., LTD.
Inventor(s)
VALENCENE SYNTHASE MUTANT AND VALENCENE HIGH-YIELD STRAIN
This abstract first appeared for US patent application 20250129357 titled 'VALENCENE SYNTHASE MUTANT AND VALENCENE HIGH-YIELD STRAIN
Original Abstract Submitted
the present disclosure belongs to the field of synthetic biology and relates to a valencene synthase mutant and a valencene high-yield strain. an enzyme for synthesizing valencene is derived from , and upon enzyme directed evolution of the enzyme, a valencene synthase mutant with improved enzyme performance is obtained, and the yield of a strain containing the mutant is 3.15 times the yield of a strain containing a wild-type synthase. the valencene synthase mutant of the present disclosure enhances the capability of synthesizing valencene by a strain, and a powerful foundation is laid for the industrial production thereof. a high-yield strain for synthesizing valencene is constructed by using the valencene synthetase mutant, and the yield of a fermentation tank reaches 12.4 g/l, which is the highest level reported to date.