University of Rochester (20250019702). GATA4-TARGETED THERAPEUTICS FOR TREATMENT OF CARDIAC HYPERTROPHY
GATA4-TARGETED THERAPEUTICS FOR TREATMENT OF CARDIAC HYPERTROPHY
Organization Name
Inventor(s)
Omar Hedaya of Rochester NY US
GATA4-TARGETED THERAPEUTICS FOR TREATMENT OF CARDIAC HYPERTROPHY
This abstract first appeared for US patent application 20250019702 titled 'GATA4-TARGETED THERAPEUTICS FOR TREATMENT OF CARDIAC HYPERTROPHY
Original Abstract Submitted
the present application provides compositions and methods for treating cardiac hypertrophy. in one embodiment, the composition comprises an antisense oligonucleotide 10-50 nucleotides in length, wherein the antisense oligonucleotide is capable of forming a double-stranded structure with a target region downstream of a start codon of an upstream open reading frame (uorf) resided within an mrna of gata4, wherein the target region spans a double-stranded stem of a stem-loop structure downstream of the gata4 uorf start codon