The regents of the university of california (20250145733). TUMOR-SPECIFIC BISPECIFIC IMMUNE CELL ENGAGER
TUMOR-SPECIFIC BISPECIFIC IMMUNE CELL ENGAGER
Organization Name
the regents of the university of california
Inventor(s)
Bin Liu of San Francisco CA US
Scott Bidlingmaier of San Francisco CA US
Yang Su of South San Francisco CA US
TUMOR-SPECIFIC BISPECIFIC IMMUNE CELL ENGAGER
This abstract first appeared for US patent application 20250145733 titled 'TUMOR-SPECIFIC BISPECIFIC IMMUNE CELL ENGAGER
Original Abstract Submitted
disclosed herein are monospecific and bispecific antibodies that comprise a alppl2/alpp-binding variable region. the bi-specific antibody is comprises of a monoclonal antibody targeting a tumor-specific cell surface antigen (alppl2/alpp) with exquisite tissue specificity and a monoclonal antibody targeting a cell surface molecule (e.g., cd3) expressed by immune effector cells.