The regents of the university of california (20250120916). NANOTECHNOLOGY FOR CHEMOTHERA0PY DRUG CAPTURE
NANOTECHNOLOGY FOR CHEMOTHERA0PY DRUG CAPTURE
Organization Name
the regents of the university of california
Inventor(s)
Amir Sheikhi of State College PA US
Alireza Khademhosseini of Los Angeles CA US
NANOTECHNOLOGY FOR CHEMOTHERA0PY DRUG CAPTURE
This abstract first appeared for US patent application 20250120916 titled 'NANOTECHNOLOGY FOR CHEMOTHERA0PY DRUG CAPTURE
Original Abstract Submitted
the instant disclosure teaches a highly efficient cellulose-based nanoadsorbent that can capture more than 6000 mg of doxorubicin (dox), one of the most widely used chemotherapy drugs, per gram of the adsorbent at physiological conditions. such drug capture capacity is more than 3200% higher than other nanoadsorbents, such as dna-based platforms. the disclosure teaches how anionic hairy cellulose nanocrystals, also known as electrosterically stabilized nanocrystalline cellulose (encc), bind to positively charged drugs in human serum and capture dox immediately without imposing any cytotoxicity and hemolytic effects. the disclosure further elucidates how encc provides a remarkable platform for biodetoxification at varying ph, ionic strength, ion type, and protein concentration. these discoveries pave the way for the next generation in vitro and in vivo drug capture additives and devices.