THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications on May 8th, 2025

Patent Applications by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA on May 8th, 2025

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA: 20 patent applications

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA has applied for patents in the areas of C12N9/22 (5), C12N15/11 (5), C12N15/90 (3), C12N15/63 (2), C07K16/28 (2) A61B3/102 (1), C07D413/12 (1), H01M4/9083 (1), G01N33/5014 (1), C12N15/907 (1)

With keywords such as: methods, disclosure, target, present, provides, provided, cell, compositions, rna, and tissue in patent application abstracts.

Patent Applications by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

20250143566. PHASE-BASED OPTORETINOGRAPHY USING TISSUE VELOCITY_simplified_abstract_(the regents of the university of california)

Inventor(s): Ravi S. Jonnal of Davis CA US for the regents of the university of california, Robert J. Zawadzki of Davis CA US for the regents of the university of california, Kari V. Vienola of Davis CA US for the regents of the university of california

IPC Code(s): A61B3/10

CPC Code(s): A61B3/102

Abstract: phase-based optoretinography (org) is performed using tissue velocity obtained from a modified optical coherence tomography (oct) system. a swept-source generated oct a-scan is used to assemble a 2-dimensional profile of the retinal tissue (b-scan) by laterally scanning the imaging beam. these b-scans can be taken at multiple time-points and assembled into a m-scan, which displays motion of a particular cross-section of retinal tissue (after correction for bulk motion). the method captures the changes between each timestep of the m-scan to deduce tissue velocities of the cost, rost, and is/os, among others. an initial contraction of outer segments is detected in outer segments, followed by an elongation shortly thereafter. the tissue velocity measurements can be used to infer retinal dysfunction without the need for costly and computationally expensive scans using adaptive optics.

20250143582. MULTIMODAL BIOMETRIC DEVICE_simplified_abstract_(the regents of the university of california)

Inventor(s): Eliah Aronoff-Spencer of San Diego CA US for the regents of the university of california, Tom Kalisky of La Jolla CA US for the regents of the university of california, Daniel Johnson of Escondido CA US for the regents of the university of california, Alex Grant of San Diego CA US for the regents of the university of california, Steve Saggese of Dan Diego CA US for the regents of the university of california

IPC Code(s): A61B5/01, A61B5/00, G06V10/143, G06V10/147, G06V40/10, G06V40/12, G06V40/13, G06V40/40, G06V40/70

CPC Code(s): A61B5/01

Abstract: a multimodal biometric device is disclosed. an apparatus may include a non-contact imaging system. the non-contact imaging system may include imaging optics, optical illumination optically coupled to the imaging optics, and a configurable body part support to support different body parts at corresponding focal lengths to capture different portions of the different body parts. an apparatus may also include a housing coupled to the imaging optics, the optical illumination, and the configurable body part support.

20250143596. GIANT MAGNETOELASTICITY ENABLED SELF-POWERED PRESSURE SENSOR FOR BIOMONITORING_simplified_abstract_(the regents of the university of california)

Inventor(s): Jun CHEN of Los Angeles CA US for the regents of the university of california

IPC Code(s): A61B5/05, A61B5/00, A61B5/11, A61B5/113, H01F7/02

CPC Code(s): A61B5/05

Abstract: the present embodiments relate generally to a soft system for producing a giant magnetoelastic effect. in some embodiments, the soft system is composed of platinum-catalyzed silicone polymer matrix and neodymium-iron-boron nanomagnets. the soft system shows up to four times more enhancement of the magnetomechanical coupling factor (t/pa) than traditional rigid counterparts owing to a distinct physical mechanism. in embodiments, the giant magnetoelastic effect is coupled with magnetic induction to implement a soft magnetoelastic generator (meg) as an approach to biomechanical energy conversion, a technology that was heretofore conventionally challenged by low current, high internal impedance, and low water/humidity resistance for decent operation stability. this new method of biomechanical-to-electrical conversion is intrinsically waterproof since the magnetic fields are able to penetrate water with negligible intensity loss. thus, it was demonstrated to work stably on wet skin or in body fluids without any encapsulation, opening up alternative avenues for practical human-body centered energy, sensing, and therapeutic applications.

20250144060. COMPOSITIONS AND METHODS FOR TREATING BIOFILMS_simplified_abstract_(the regents of the university of california)

Inventor(s): Clarissa J. Nobile of Merced CA US for the regents of the university of california, Megha Gulati of Merced CA US for the regents of the university of california

IPC Code(s): A61K31/198, A61K47/10, A61P31/04

CPC Code(s): A61K31/198

Abstract: the disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans.

20250144144. BISPECIFIC OR-GATE CHIMERIC ANTIGEN RECEPTOR RESPONSIVE TO CD20 and CD19_simplified_abstract_(the regents of the university of california)

Inventor(s): Yvonne Y. Chen of Los Angeles CA US for the regents of the university of california, Eugenia Zah of Los Angeles CA US for the regents of the university of california, Michael C. Jensen of Seattle WA US for the regents of the university of california

IPC Code(s): A61K35/17, A61K38/00, A61K39/00, A61K40/11, A61K40/31, A61K40/42, C07K14/705, C07K14/725, C07K16/28, C07K16/46, C12N5/0783

CPC Code(s): A61K35/17

Abstract: a cd19-or-cd20 chimeric antigen receptor (car) protein construct is provided. also provided are nucleic acids encoding the cd19-or-cd20 car; and methods of use, e.g. in the treatment of b cell malignancies. the cd19-or-cd20 car of the invention is a bispecific car that can trigger t-cell activation upon detection of either cd19 or cd20 (or both). it is a single molecule that confers two-input recognition capability upon human t cells engineered to stably express this car.

20250144147. BASE EDITING AND CRISPR/CAS9 GENE EDITING STRATEGIES TO CORRECT CD3 SEVERE COMBINED IMMUNODEFICIENCY IN HEMATOPOIETIC STEM CELLS_simplified_abstract_(the regents of the university of california)

Inventor(s): Donald B. KOHN of Tarzana CA US for the regents of the university of california, Grace MCAULEY of Los Angeles CA US for the regents of the university of california

IPC Code(s): A61K35/28, A61P37/04, C12N9/22, C12N15/11, C12N15/86, C12N15/90

CPC Code(s): A61K35/28

Abstract: provided herein are compositions, systems, and methods to provide two gene editing-based approaches that can be used to correct the cd35 scid-causing c202t mutation (tga→cga). in certain embodiments one approach involves crispr/cas9 homology-directed repair (hdr)-mediated correction with a single-strand oligodeoxynucleotide (ssodn) homologous donor. in certain embodiments another approach comprises adenine base editing (abe)-correction, to precisely revert the cd35 scid-causing c202t mutation (tga→cga).

20250144224. ABL INHIBITORS AND USES THEREOF_simplified_abstract_(the regents of the university of california)

Inventor(s): Kevan M. Shokat of San Francisco CA US for the regents of the university of california, Kevin Lou of San Francisco CA US for the regents of the university of california, Jack W. Stevenson of San Francisco CA US for the regents of the university of california

IPC Code(s): A61K47/55, A61K47/54, A61K47/60

CPC Code(s): A61K47/55

Abstract: described herein, inter alia, are abl inhibitors and uses thereof.

20250144241. METHODS OF TARGETING REPETITIVE RNA IN HUNTINGTON'S DISEASE_simplified_abstract_(the regents of the university of california)

Inventor(s): Eugene Yeo of La Jolla CA US for the regents of the university of california, Kathryn H. Morelli of Encinitas CA US for the regents of the university of california

IPC Code(s): A61K48/00, C12N9/22, C12N15/11, C12N15/86

CPC Code(s): A61K48/005

Abstract: provided herein are methods of treating huntington's disease in a subject, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising: (a) a guide rna (grna), wherein the guide rna comprises a repeat sequence complementary to a target cag-expansion rna, and wherein the grna allele-selectively targets the target cag-expansion rna; and (b) a crispr-associated protein or a nucleic acid sequence encoding the crispr-associated protein, wherein the crispr-associated protein comprises a cas13d polypeptide.

20250145598. ACID CERAMIDASE INHIBITORS AND USES THEREOF_simplified_abstract_(the regents of the university of california)

Inventor(s): Jennifer Y. Chen of San Francisco CA US for the regents of the university of california, William F. DeGrado of San Francisco CA US for the regents of the university of california, Hyunil Jo of Lafayette CA US for the regents of the university of california, Richard Beresis of San Francisco CA US for the regents of the university of california, Marc Adler of Orinda CA US for the regents of the university of california

IPC Code(s): C07D413/12, A61K31/4178, A61K31/4192, A61K31/4196, A61K31/4245, A61K31/427, A61K31/4439, A61K31/496, A61K31/501, A61K31/506, A61K31/5377, C07D233/64, C07D401/12, C07D401/14, C07D403/12, C07D403/14, C07D405/14, C07D413/14, C07D417/14

CPC Code(s): C07D413/12

Abstract: described herein, inter alia, are acid ceramidase inhibitors and uses thereof.

20250145634. COMPOSITIONS AND METHODS FOR TREATING CANCER_simplified_abstract_(the regents of the university of california)

Inventor(s): David A. Nathanson of Los Angeles CA US for the regents of the university of california, Michael E. Jung of Los Angeles CA US for the regents of the university of california, Jonathan Tsang of Los Angeles CA US for the regents of the university of california, Lorenz Urner of Los Angeles CA US for the regents of the university of california, Peter M. Clark of Los Angeles CA US for the regents of the university of california, Timothy F. Cloughesy of Calabasas CA US for the regents of the university of california, Gyudong Kim of Seoul KR for the regents of the university of california

IPC Code(s): C07D491/056, C07D239/94, C07D239/95, C07D405/04

CPC Code(s): C07D491/056

Abstract: the present disclosure relates to compounds that are capable of penetrating the blood brain barrier to modulate the activity of egfr tyrosine kinase. the disclosure further relates to methods of treating glioblastoma and other egfr-mediated cancers, such as those that have been determined to have altered glucose metabolism in the presence of inhibitors. the present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.

20250145733. TUMOR-SPECIFIC BISPECIFIC IMMUNE CELL ENGAGER_simplified_abstract_(the regents of the university of california)

Inventor(s): Bin Liu of San Francisco CA US for the regents of the university of california, Scott Bidlingmaier of San Francisco CA US for the regents of the university of california, Yang Su of South San Francisco CA US for the regents of the university of california

IPC Code(s): C07K16/40, C07K16/28, G01N33/574

CPC Code(s): C07K16/40

Abstract: disclosed herein are monospecific and bispecific antibodies that comprise a alppl2/alpp-binding variable region. the bi-specific antibody is comprises of a monoclonal antibody targeting a tumor-specific cell surface antigen (alppl2/alpp) with exquisite tissue specificity and a monoclonal antibody targeting a cell surface molecule (e.g., cd3) expressed by immune effector cells.

20250145959. COMPOSITIONS AND METHODS FOR PRODUCING SMOOTH MUSCLE CELLS_simplified_abstract_(the regents of the university of california)

Inventor(s): Rustam Esanov of San Francisco CA US for the regents of the university of california, Yeqing Angela Yang of San Francisco CA US for the regents of the university of california, Volkan Sevim of San Francisco CA US for the regents of the university of california, Kaivalya Shevade of Oakland CA US for the regents of the university of california, Laralynne Przybyla of Oakland CA US for the regents of the university of california, Shawn Shafer of Philadelphia PA US for the regents of the university of california

IPC Code(s): C12N5/077, C12N9/22, C12N15/11, C12N15/90

CPC Code(s): C12N5/0661

Abstract: methods and compositions are provided for producing a smooth muscle cell (smc) from a pluripotent stem cell, e.g., an induced pluripotent stem cell (ipsc), via meox1 overexpression. meox1 expression can be induced using any convenient method, e.g., by introducing an exogenous nucleic acid encoding meox1 or by using a tool such as crispra to stimulate expression from the meox1 endogenous locus.

20250145968. GENETIC ENGINEERING OF BACTERIOPHAGES USING CRISPR-CAS13A_simplified_abstract_(the regents of the university of california)

Inventor(s): Joseph Bondy-Denomy of Oakland CA US for the regents of the university of california, Jingwen Guan of Oakland CA US for the regents of the university of california, Senen Mendoza of Oakland CA US for the regents of the university of california

IPC Code(s): C12N7/00, C12N9/22, C12N15/11, C12N15/63

CPC Code(s): C12N7/00

Abstract: the present disclosure provides methods and compositions for modifying the genomes of bacteriophages, in particular by integrating a coding sequence for an anti-crispr protein into the bacteriophage genome together with a desired modification such as a deletion, insertion, or nucleotide substitution, and selecting for bacteriophages with the integrated anti-crispr coding sequence by introducing the phage into a counter selection strain comprising an rna-targeting crispr-cas system.

20250146024. Methods and Compositions for RNA-Directed Target DNA Modification and For RNA-Directed Modulation of Transcription_simplified_abstract_(the regents of the university of california)

Inventor(s): Jennifer A. Doudna of Berkeley CA US for the regents of the university of california, Martin Jinek of Berkeley CA US for the regents of the university of california, Krzysztof Chylinski of Vienna AT for the regents of the university of california, Emmanuelle Charpentier of Berlin DE for the regents of the university of california

IPC Code(s): C12N15/90, A01H6/46, A01K67/027, A61K38/46, A61K48/00, C12N9/22, C12N15/10, C12N15/11, C12N15/113, C12N15/63, C12N15/70, C12N15/74, C12Q1/686, H01L21/02, H10H20/01

CPC Code(s): C12N15/907

Abstract: the present disclosure provides a dna-targeting rna that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target dna and/or a polypeptide associated with the target dna. the present disclosure further provides site-specific modifying polypeptides. the present disclosure further provides methods of site-specific modification of a target dna and/or a polypeptide associated with the target dna the present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive cas9 polypeptide and a dna-targeting rna. kits and compositions for carrying out the methods are also provided. the present disclosure provides genetically modified cells that produce cas9; and cas9 transgenic non-human multicellular organisms.

20250147006. MULTI-DEPTH SPIRAL MILLI FLUIDIC DEVICE FOR WHOLE MOUNT ZEBRAFISH ANTIBODY STAINING_simplified_abstract_(the regents of the university of california)

Inventor(s): Songtao Ye of Half Moon Bay CA US for the regents of the university of california, Chih-Wen Ni of Castro Valley CA US for the regents of the university of california

IPC Code(s): G01N33/50, C12M1/00, C12M1/34, C12M3/06

CPC Code(s): G01N33/5014

Abstract: fluidic systems, devices and methods are provided for separating and sequestering particles from a fluid flow within traps in a fluidic chip is provided. the fluidic platform is particularly suited for parallel live zebrafish embryo studies providing automated zebrafish embryo trapping and flow through culture as well as whole mount zebrafish antibody staining functions. the zebrafish on a chip testing platform uses a chaotic hydrodynamic trapping process to trap and retain zebrafish embryos in a consistent body orientation (i.e., head pointed inward) without any external adjustments. the system and apparatus can also be adapted to be a multifunctional concentration gradient generator (cgg) that can be used to automatically immobilize dechorionated zebrafish embryos and generate chemical gradients for acute fish embryo toxicity (fet) tests.

20250149601. CATALYSTS AND METHODS FOR MAKING AND USING THE SAME_simplified_abstract_(the regents of the university of california)

Inventor(s): Shaowei Chen of Santa Cruz CA US for the regents of the university of california, Bingzhang Lu of Santa Cruz CA US for the regents of the university of california, Qiming Liu of Santa Cruz CA US for the regents of the university of california

IPC Code(s): H01M4/90, C01G53/40, C25B11/052, C25B11/065, C25B11/077, H01M4/92

CPC Code(s): H01M4/9083

Abstract: a method for making a catalyst composition is disclosed. the method includes placing a substrate with at least one precursor composition disposed thereon in contact with a ferromagnetic material and placing the substrate and the ferromagnetic material within an induction solenoid. the method further includes generating an alternating magnetic field within the induction solenoid upon energization by a power source supplying alternating current, thereby heating the substrate and the ferromagnetic material to a temperature of from about 200 c to about 1,500 c. the method additionally includes rapidly cooling the substrate and the ferromagnetic material

20250149855. SYSTEMS AND METHODS FOR SCALING ELECTROMAGNETIC APERTURES, SINGLE MODE LASERS, AND OPEN WAVE SYSTEMS_simplified_abstract_(the regents of the university of california)

Inventor(s): Boubacar KANTE of Berkeley CA US for the regents of the university of california, Rushin MANAN CONTRACTOR of Berkeley CA US for the regents of the university of california, Wanwoo NOH of Berkeley CA US for the regents of the university of california, Walid REDJEM of Berkeley CA US for the regents of the university of california

IPC Code(s): H01S5/11, H01S5/00, H01S5/024, H01S5/10

CPC Code(s): H01S5/11

Abstract: a surface-emitting, single mode laser includes a gain medium and a photonic structure. the gain medium is configured to emit an electromagnetic wave. the photonic structure is electromagnetically coupled to the gain medium and has a cavity mode-dependent scaling of losses so that higher order modes are coupled to more lossy bands and a fundamental mode, at a high symmetry point, is coupled to a less lossy band of the photonic structure.

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications on May 8th, 2025