THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications on May 1st, 2025
Patent Applications by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA on May 1st, 2025
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA: 21 patent applications
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA has applied for patents in the areas of C12N15/11 (3), A61B5/00 (2), C12N5/0783 (2), H01M50/105 (2), G01N33/68 (2) C12Q1/6883 (2), H01M10/0468 (2), C12Q1/6825 (1), H01J37/20 (1), G16H50/20 (1)
With keywords such as: nucleic, methods, data, signal, acid, risk, electrode, binding, sensor, and include in patent application abstracts.
Patent Applications by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor(s): Yama Akbari of Irvine CA US for the regents of the university of california, Robert H. Wilson of Irvine CA US for the regents of the university of california, Christian Crouzet of Irvine CA US for the regents of the university of california, Thomas Milner of Irvine CA US for the regents of the university of california, Bernard Choi of Irvine CA US for the regents of the university of california
IPC Code(s): A61B5/026, A61B5/00, A61B5/1455
CPC Code(s): A61B5/0261
Abstract: a portable device for quantitative measurement of tissue autoregulation and neurovascular coupling via portable measurement of blood flow, oxygenation, metabolism, and/or eeg signals and methods for using said device. the device may comprise a body and a plurality of legs pivotably attached to the body. the plurality of legs may comprise at least one reference electrode leg and at least one measurement electrode leg for electrical measurement, and an optical detection fiber leg and at least one optical source fiber leg for optical blood flow, oxygenation, and metabolism measurement. the present invention is additionally directed to a portable device for blood flow measurement and therapeutic photobiomodulation. the device may comprise a body and a plurality of legs. the plurality of legs may comprise at least one optical detection fiber leg and at least one optical source fiber leg, and at least one leg for therapeutic photobiomodulation.
Inventor(s): Jennifer Graves of Encinitas CA US for the regents of the university of california, Tzyy-Ping Jung of San Diego CA US for the regents of the university of california, Masaki Nakanishi of San Diego CA US for the regents of the university of california
IPC Code(s): A61B5/00, A61B3/113, A61B5/378, A61B5/398
CPC Code(s): A61B5/4076
Abstract: methods and systems for assessing afferent and efferent visual functions are disclosed. in one aspect, a wearable system for concurrently assessing afferent and efferent visual functions includes a display configured to be placed in front of a face of a user and provide visual stimuli to the user to elicit eye movements, an electroencephalography (eeg) sensor configured to be placed on a head of the user to measure electrical activity in a brain of the user that occurs in response to the visual stimuli, an eye-tracker configured to track the eye movements, and a processor coupled to the display, the electroencephalography sensor, and the eye-tracker to: cause the visual stimuli to be presented on the display; obtain an electroencephalography signal from the eeg sensor; obtain eye-tracking measurements from the eye-tracker; and determine, based on the electroencephalography signal and the eye-tracking measurements, information associated with the afferent and efferent visual functions.
Inventor(s): Andrei M. SHKEL of Irvine CA US for the regents of the university of california, Danmeng WANG of Irvine CA US for the regents of the university of california, Austin R. PARRISH of Irvine CA US for the regents of the university of california
IPC Code(s): B81C1/00
CPC Code(s): B81C1/00626
Abstract: systems, processes and devices are provided for wafer-level fabrication of a resonator. a process is provided that includes chemical etching of glass and silicon, high-temperature glassblowing, controlling assembly of at least one yig sphere relative to a nest structure, and plasma assisted wafer bonding. the process can include formation of loop coils and spherical coils defined by the glassblowing process including inner and outer hemispherical structures. the inner hemispherical structure may provide loops to drive and detect resonance in yig spheres. processes discussed herein allow for placement of loops in close proximity (e.g., few microns) to ferrimagnetic elements. the outer hemisphere may provide harmonic magnetic coils for frequency tuning. embodiments are also directed to a resonator including first and second wafer-level glass blown wafer stacks each with inner hemisphere and outer hemispheres. the resonator includes coupling loop coils, tuning coils, and a sphere element nested between glass blown wafer stacks.
Inventor(s): Matthew KIM of San Francisco CA US for the regents of the university of california, Hana EL-SAMAD of San Francisco CA US for the regents of the university of california, Andrew H. NG of San Francisco CA US for the regents of the university of california
IPC Code(s): C07K14/47, C07K5/11, C07K7/06, C12N5/0783, C12N15/86
CPC Code(s): C07K14/4702
Abstract: described herein, among other things, is a fusion protein for degrading a target protein in trans. the fusion protein may comprise a lysine-free alpha-helical heterodimerization domain and a c-terminal degron. degrons are believed to act as a degradation signal that recruits the proteosome to the target protein, thereby degrading the protein. a nucleic acid encoding the same and a cell containing the nucleic acid and a target protein are also described.
Inventor(s): Chia-Yung Wu of San Francisco CA US for the regents of the university of california, James Onuffer of Alameda CA US for the regents of the university of california, Wendell A. Lim of San Francisco CA US for the regents of the university of california
IPC Code(s): C07K14/705, A61K35/17, A61K39/00, A61K40/11, A61K40/31, A61K40/42, A61K47/68, C07K14/725, C07K16/18, C07K16/28, C12N5/0783, C12N9/14, C12N9/90
CPC Code(s): C07K14/705
Abstract: the present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (car), and a nucleic acid comprising a nucleotide sequence encoding the car. the present disclosure provides cells genetically modified to produce the car. a car of the present disclosure can be used in various methods, which are also provided.
Inventor(s): Karen Christman of San Diego CA US for the regents of the university of california, Masaki Fujita of San Diego CA US for the regents of the university of california, Michael Madani of La Jolla CA US for the regents of the university of california
IPC Code(s): C08G65/48, A61L31/06, A61L31/14, A61L31/16
CPC Code(s): C08G65/48
Abstract: methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. the hydrogels generally include at least three component polymers, a first polymer including an aminooxy group, a second polymer including a reactive oxo group, that are cross-linked by oxime bonds and a third polymer including a catechol group, that causes better retention on the cardiac tissue. the hydrogels are suitable for binding to and coating a tissue or cell. the hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
Inventor(s): Kaivalya Shevade of Oakland CA US for the regents of the university of california, Rustam Esanov of San Francisco CA US for the regents of the university of california, Yeqing Angela Yang of San Francisco CA US for the regents of the university of california, Volkan Sevim of San Francisco CA US for the regents of the university of california, Laralynne Przybyla of Oakland CA US for the regents of the university of california, Shawn Shafer of San Francisco CA US for the regents of the university of california
IPC Code(s): C12N5/0735, C12N9/22, C12N15/11, C12N15/90
CPC Code(s): C12N5/0611
Abstract: methods and compositions are provided for producing a primordial germ cell like cell (pgclc) from a pluripotent stem cell, e.g., an induced pluripotent stem cell (ipsc), via gata5 overexpression. gata5 expression can be induced using any convenient method, e.g., by introducing an exogenous nucleic acid encoding gata5 or by using a tool such as crispra to stimulate expression from the gata5 endogenous locus.
Inventor(s): Hugh E. Olsen of Santa Cruz CA US for the regents of the university of california, Miten Jain of Santa Cruz CA US for the regents of the university of california, Mark A. Akeson of Santa Cruz CA US for the regents of the university of california
IPC Code(s): C12N15/10, C12N15/11, C12Q1/6806, C40B30/04, C40B40/06, C40B70/00
CPC Code(s): C12N15/1065
Abstract: provided are methods of producing size-selected nucleic acid libraries. the methods include contacting a nucleic acid sample and a nucleic acid binding reagent including an affinity tag, under conditions in which nucleic acids of less than a desired length are substantially bound to the nucleic acid binding reagent and nucleic acids of the desired length are substantially not bound to the nucleic acid binding reagent. the conditions include the duration of the contacting, the concentration of the nucleic acid binding reagent, or both. the methods further include separating, using the affinity tag, the nucleic acids of less than the desired length bound to the nucleic acid binding reagent from the nucleic acids of the desired length not bound to the nucleic acid binding reagent, to produce a size-selected nucleic acid library. compositions and kits that find use, e.g., in practicing the methods of the present disclosure, are also provided.
Inventor(s): Alyssa Jasmine Chiang of La Jolla CA US for the regents of the university of california, Jeff Hasty of Encinitas CA US for the regents of the university of california
IPC Code(s): C12Q1/02, C12N15/70, G01N21/64, G01N33/18, G16B40/20
CPC Code(s): C12Q1/02
Abstract: described herein are methods, compositions, and systems for determining an analyte in a sample. method of determining an amount of an analyte in a sample using an adapted bio sensing microbe can include inducing an adapted bio sensing microbe containing an inducible promoter operably linked to a gene encoding a signal, wherein the inducible promoter is induced by the analyte to produce the signal; measuring the signal; and determining, in response to the signal, the amount of the analyte. the sample can include a high salinity medium (e.g., groundwater, seawater, road run-off water, anaerobic bioreactor water, and sewer water). the analyte can include heavy metal.
Inventor(s): Drew Hall of La Jolla CA US for the regents of the university of california, Chung-Lun Hsu of Walnut CA US for the regents of the university of california, Alexander Sun of San Mateo CA US for the regents of the university of california, Yunting Zhao of San Diego CA US for the regents of the university of california, Eliah Aronoff-Spencer of San Diego CA US for the regents of the university of california
IPC Code(s): C12Q1/6825, G01N27/02
CPC Code(s): C12Q1/6825
Abstract: disclosed are biosensor devices, systems, and methods for point-of-care applications. in some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.
Inventor(s): Janine M. LaSalle of Davis CA US for the regents of the university of california
IPC Code(s): C12Q1/6883, A61K31/7105, A61K38/17, C12N15/11, C12Q1/6844, C12Q1/6869
CPC Code(s): C12Q1/6883
Abstract: described are methods for identifying an asd risk gene, nhip, and methods for determining the risk of an offspring for developing an asd. a common structural variant disrupting the proximity of nhip to a fetal brain enhancer was associated with nhip expression and methylation levels and asd risk, demonstrating a common genetic influence. nhip is a novel environmentally-responsive asd risk gene relevant to brain development in a previously under characterized region of the human genome.
Inventor(s): Jonathan Z. Pan of Oakland CA US for the regents of the university of california, Zhonghui Guan of Oakland CA US for the regents of the university of california, Hua Su of Oakland CA US for the regents of the university of california
IPC Code(s): C12Q1/6883, G01N33/68
CPC Code(s): C12Q1/6883
Abstract: the current medical managements of cns injuries, such as spinal cord injury (sci), io traumatic brain injury (tbi) or stroke are far from ideal. clinical trials in acute cns injuries are challenging because of multiple barriers, such as heterogeneity of the injury and limitations of the imaging test and functional examination to identify the degrees of injuries. therefore, there are urgent needs for identifying a biomarke that can be employed by clinicians to objectively stratify patients' initial severity of injuries as well as monitor injury progression and response to treatment.
Inventor(s): Hannah Kathryn Carter of San Diego CA US for the regents of the university of california, Meghana Sai Pagadala of La Jolla CA US for the regents of the university of california, Jorge Silvio Gutkind of La Jolla CA US for the regents of the university of california, Victoria Huannyun Wu of La Jolla CA US for the regents of the university of california, Maurizio Zanetti of La Jolla CA US for the regents of the university of california
IPC Code(s): C12Q1/6886, A61K45/06
CPC Code(s): C12Q1/6886
Abstract: provided herein are methods of improving sensitivity to immune checkpoint blockade (icb) in a subject with a solid tumor cancer, the method comprising: administering to the subject with a solid tumor cancer an inhibitor of a tumor immune microenvironment (time) gene, wherein the time gene is selected from the group consisting of slc11a1, ccbl2, lilrb2, lilrb4, lair1, ctss, ctsw, b2m, haus1, ms4a4a, fcgr2b, lyz, and gnptab, thereby improving sensitivity to icb in the subject with a solid tumor cancer.
Inventor(s): Aydogan Ozcan of Los Angeles CA US for the regents of the university of california, Deniz Mengu of Los Angeles CA US for the regents of the university of california
IPC Code(s): G02B21/14, G02B27/42, G02B27/52
CPC Code(s): G02B21/14
Abstract: quantitative phase imaging (qpi) is a label-free computational imaging technique that provides optical path length information of objects. here, a diffractive qpi network architecture is disclosed that can synthesize the quantitative phase image of an object by converting the input phase information of a scene or object(s) into intensity variations at the output plane. a diffractive qpi network is a specialized all-optical device designed to perform a quantitative phase-to-intensity transformation through passive diffractive/reflective surfaces that are spatially engineered using deep learning and image data. forming a compact, all-optical network that axially extends only �200-300� (�=illumination wavelength), this framework replaces traditional qpi systems and related digital computational burdens with a set of passive substrate layers. all-optical diffractive qpi networks can potentially enable power-efficient, high frame-rate and compact phase imaging systems that might be useful for various applications, including, e.g., on-chip microscopy and sensing.
Inventor(s): Nader Fathy of La Jolla CA US for the regents of the university of california, Patrick Mercier of La Jolla CA US for the regents of the university of california
IPC Code(s): G06F3/01, H03M1/66
CPC Code(s): G06F3/015
Abstract: a method for obtaining neural signals from a neural signal sensor includes extracting sensor offset from a neural input signal. sensor offset is removed from n-channels that share a single amplifier. the neural input signal is acquired from the analog domain by neural electrodes with varying dc-offset and the method includes multiplexing the n-channels via a time divisional multiple access procedure into a single neural amplifier an integrated digitally assisted neural recording system includes an analog multiplexer structured to receive n-channels and to multiplex the n-channels into a single neural amplifier. a feedback loop is configured to cancel electrode offset voltage in the digital domain by generating electrode offset voltage samples and adding delay to align each electrode offset voltage sample to be subtracted at the neural amplifier in the analog domain.
Inventor(s): Guann Pyng Li of Irvine CA US for the regents of the university of california, Yutian Ren of Irvine CA US for the regents of the university of california
IPC Code(s): G06N3/088
CPC Code(s): G06N3/088
Abstract: a system for automatically self-labeling a digital dataset includes a first sensor for generating a first data stream, a second sensor for collecting information to generate a second data stream, and a causal model manager (cmm). the cmm is configured to determine a first causal event from a first data segment of the first data stream, and a causal relation between the first causal event and a second data segment selected from the second data stream. the system further includes (a) an interactive time model for determining an interaction time between the first and second data segments, and (b) a self-labeling subsystem configured to derive a label from the second data segment, associate the first data segment with the derived label, form a self-labeled data pair from the associated first data segment and the derived label, and automatically annotate the self-labeled data pair with the interaction time.
Inventor(s): Laura Jelliffe of San Francisco CA US for the regents of the university of california, Kelli Ryckman of Iowa City IA US for the regents of the university of california, Jeffrey Murray of Iowa City IA US for the regents of the university of california
IPC Code(s): G16H50/20, G01N33/68, G16H10/40, G16H20/10, G16H40/63, G16H50/30, G16H50/50, G16H50/70
CPC Code(s): G16H50/20
Abstract: a method of treating preterm birth (ptb) risk in a subject is disclosed. an example method may obtain risk indicator values for two or more risk indicators selected from a panel of risk indicators comprising the group consisting of: afp, anemia status, assistance status, body mass index, cd40l, cholesterol, crp, diabetes status, ena78, eotaxin, gp130, hcg, hdl, hgf, hypertension status, icam1, ifna, ifnb, il-10, il-13, il-15, il-1a, il-1ra, il-4, il-5, il-6, il-7, il-8, il1r1, il4r, inh, ip-10, ldl, lif, mcp3, mcsf, mig, mip1a, mip1b, ngf, papp-a, parity, pdgfbb, progesterone, rantes, ratio of triglycerides to hdl, sfasl, tnfr1, trail, triglycerides, vegf, vegfr1, vegfr2, and vegfr3. the example method may input the obtained risk indicator values into a predictive model to calculate a predictive score indicative of ptb risk, determine the subject has an elevated risk of ptb risk based upon the predictive score, and administer an intervention to the subject.
Inventor(s): Haimei Zheng of Berkeley CA US for the regents of the university of california, Sophia Betzler of Berkeley CA US for the regents of the university of california, Jiawei Wan of Albany CA US for the regents of the university of california, Qiubo Zhang of Albany CA US for the regents of the university of california, Xianhu Sun of EL Cerrito CA US for the regents of the university of california
IPC Code(s): H01J37/20, H01J37/26
CPC Code(s): H01J37/20
Abstract: this disclosure provides systems, methods, and apparatus related to liquid cells for use in transmission electron microscopy (tem). in one aspect, as assembly includes a first tem element and a second tem element. the first tem element comprises a grid with a first oxide disposed thereon, a first polymer layer disposed on the first oxide, and a first electrode and a second electrode disposed on the first polymer layer. the second tem element comprises a second grid having a second oxide disposed thereon and a second polymer layer disposed on the second oxide. the second tem element has a circular shape with a portion of the circular shape being removed such that an end of the first electrode and an end of the second electrode are exposed when the second tem element is placed on top of the first tem element to form the assembly.
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications on May 1st, 2025
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- A61B5/026
- A61B5/00
- A61B5/1455
- CPC A61B5/0261
- The regents of the university of california
- A61B3/113
- A61B5/378
- A61B5/398
- CPC A61B5/4076
- B81C1/00
- CPC B81C1/00626
- C07K14/47
- C07K5/11
- C07K7/06
- C12N5/0783
- C12N15/86
- CPC C07K14/4702
- C07K14/705
- A61K35/17
- A61K39/00
- A61K40/11
- A61K40/31
- A61K40/42
- A61K47/68
- C07K14/725
- C07K16/18
- C07K16/28
- C12N9/14
- C12N9/90
- CPC C07K14/705
- C08G65/48
- A61L31/06
- A61L31/14
- A61L31/16
- CPC C08G65/48
- C12N5/0735
- C12N9/22
- C12N15/11
- C12N15/90
- CPC C12N5/0611
- C12N15/10
- C12Q1/6806
- C40B30/04
- C40B40/06
- C40B70/00
- CPC C12N15/1065
- C12Q1/02
- C12N15/70
- G01N21/64
- G01N33/18
- G16B40/20
- CPC C12Q1/02
- C12Q1/6825
- G01N27/02
- CPC C12Q1/6825
- C12Q1/6883
- A61K31/7105
- A61K38/17
- C12Q1/6844
- C12Q1/6869
- CPC C12Q1/6883
- G01N33/68
- C12Q1/6886
- A61K45/06
- CPC C12Q1/6886
- G02B21/14
- G02B27/42
- G02B27/52
- CPC G02B21/14
- G06F3/01
- H03M1/66
- CPC G06F3/015
- G06N3/088
- CPC G06N3/088
- G16H50/20
- G16H10/40
- G16H20/10
- G16H40/63
- G16H50/30
- G16H50/50
- G16H50/70
- CPC G16H50/20
- H01J37/20
- H01J37/26
- CPC H01J37/20
- H01M50/105
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