THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications on February 27th, 2025
Patent Applications by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA on February 27th, 2025
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA: 19 patent applications
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA has applied for patents in the areas of A61K39/00 (3), A61B5/0205 (2), B01J20/22 (2), C07K16/28 (2), C07F5/06 (2) A61B5/1486 (1), C08G61/02 (1), G09B19/003 (1), G06T11/005 (1), G01N25/18 (1)
With keywords such as: methods, subject, image, spinal, provided, plasma, serum, sample, data, and disease in patent application abstracts.
Patent Applications by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor(s): Joseph Wang of San Diego CA (US) for the regents of the university of california, Jong-Min Moon of La Jolla CA (US) for the regents of the university of california, Lu Yin of San Diego CA (US) for the regents of the university of california
IPC Code(s): A61B5/1486, A61B5/0205, A61B5/145
CPC Code(s): A61B5/1486
Abstract: methods, materials and devices that pertain to solid-state gel-free sensor for touch-based rapid physiological and chemical sensing are disclosed. in some embodiments of the disclosed technology, a sensor device includes a substrate, a plurality of first electrodes and a plurality of second electrodes formed over the substrate, a first current collector formed over the substrate and coupled to the plurality of first electrodes at one end of each first electrode, and a second current collector formed over the substrate and coupled to the plurality of second electrodes at one end of each second electrode, wherein the first electrodes and the second electrodes are alternately arranged, and adjacent first and second electrodes are spaced apart from each other by a predetermined distance.
Inventor(s): Michael Karin of La Jolla CA (US) for the regents of the university of california, Hongxu Xian of La Jolla CA (US) for the regents of the university of california
IPC Code(s): A61K31/517, A61P37/06, C12N15/113
CPC Code(s): A61K31/517
Abstract: provided herein are methods for treating a disease or condition associated with one or more of: mtdna fragmentation; cytostolic ox-mtdna; mtdna release; or casp1 activation and il-1� production by administering an effective amount of an inhibitor of human flap endonuclease-1 (fen1). these diseases include without limitation, an inflammatory or a neurodegenerative disease, such as alzheimer's, disease, parkinson's disease, atherosclerosis, nash, asthma, inflammatory bowel disease, melanoma, metabolic pathologies, including obesity, type 2 diabetes, atherosclerosis, inflammatory bowel diseases, gout, and periodic fevers.
Inventor(s): Justin Karlin of Los Angeles CA (US) for the regents of the university of california
IPC Code(s): A61K35/16, A61F9/00, A61K9/00, A61K47/10, A61K47/36
CPC Code(s): A61K35/16
Abstract: a method of producing serum or plasma comprises the steps of drawing a blood sample from a subject; adding erythrocyte sedimentation-accelerating agent(s) and an anticoagulant to the blood sample; placing the mixture in a vessel with an inclined well and allowing the phase separation of the solution into an erythrocyte phase and a plasma or serum phase, producing an erythrocyte-depleted serum or plasma; and collecting the erythrocyte-depleted serum or plasma. a method of producing an ophthalmic solution (“eye drops”) meant for lubricating the eye of a subject comprises the steps of drawing a blood sample from a subject; adding erythrocyte sedimentation-accelerating agent(s) and an anticoagulant to the blood sample; placing the mixture in a vessel with an inclined well and allowing the phase separation of the solution into an erythrocyte phase and a plasma or serum phase, producing an erythrocyte-depleted serum or plasma; collecting the erythrocyte-depleted serum or plasma; treating the plasma with a platelet activating substance or agent; and applying the erythrocyte-depleted serum or plasma to the eye of the subject. a kit provides components, diagrams, compositions and instructions for performing the methods.
Inventor(s): Anahid Jewett of Los Angeles CA (US) for the regents of the university of california
IPC Code(s): A61K35/745, A61K31/198, A61K31/337, A61K31/4985, A61K31/519, A61K33/243, A61K35/00, A61K35/744, A61K35/747, A61K39/00, A61K39/395, A61P35/00
CPC Code(s): A61K35/745
Abstract: the present application relates to probiotic compositions comprising two or more bacterial strains selected from: , and
Inventor(s): Omar M. Yaghi of Berkeley CA (US) for the regents of the university of california, Nikita Hanikel of Berkeley CA (US) for the regents of the university of california, Zhiling Zheng of Berkeley CA (US) for the regents of the university of california
IPC Code(s): B01J20/22, B01D53/02, B01J20/28, B01J20/30, C07F5/06
CPC Code(s): B01J20/226
Abstract: multivariate metal-organic framework (mtv-mof) composition are synthesized in a hydrothermal reaction between a metal and deprotonated linkers mixed at different ratios in a relatively rapid, facile, scalable, and high-yield synthesis method of the mtv-mof on a kilogram-scale.
Inventor(s): Ranjan Dohil of San Diego CA (US) for the regents of the university of california, Carlo Ballatore of San Diego CA (US) for the regents of the university of california
IPC Code(s): C07C327/30, A61K31/223, A61K31/265, A61P1/16, C07C323/58
CPC Code(s): C07C327/30
Abstract: the disclosure provides for cysteamine prodrugs, pharmaceutical compositions made thereof, and methods thereof including the treatment of any disease or disorder in a subject that can benefit from one or more of the bioprotective effects of cysteamine, including but not limited to, binding of cystine, reducing oxidative stress, increasing adiponectin levels and/or increasing brain-derived neurotrophic factors. examples of such disease and disorders, include but are not limited to, cystinosis, and fatty liver diseases including non-alcoholic steatohepatitis (nash).
Inventor(s): Omar M. Yaghi of Berkeley CA (US) for the regents of the university of california, Nikita Hanikel of Berkeley CA (US) for the regents of the university of california, Daria V. Kurandina of Berkeley CA (US) for the regents of the university of california
IPC Code(s): C07F5/06, B01J20/22
CPC Code(s): C07F5/069
Abstract: novel water-stable metalorganic framework (mof) composition with linker extension/functionalization provide higher water uptake at low relative humidity.
Inventor(s): Dylan Conklin of Los Angeles CA (US) for the regents of the university of california, Martina S. McDermott of Los Angeles CA (US) for the regents of the university of california, Neil A. O'Brien of Los Angeles CA (US) for the regents of the university of california, Michael J. Palazzolo of Los Angeles CA (US) for the regents of the university of california, Dennis Slamon of Los Angeles CA (US) for the regents of the university of california, Erika Von Euw of Los Angeles CA (US) for the regents of the university of california, Peter Bowers of Los Angeles CA (US) for the regents of the university of california
IPC Code(s): C07K16/28, A61K39/00, A61K47/65, A61K47/68, A61P35/00, G01N33/574
CPC Code(s): C07K16/28
Abstract: the present disclosure provides antigen-binding proteins which bind to claudin-6 (cldn6). in various aspects, the antigen-binding proteins bind to extracellular loop 2 (el2) of the extracellular domain of cldn6. related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. kits and pharmaceutical compositions comprising such entities are moreover provided. also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.
Inventor(s): Roger S. Lo of LOS ANGELES CA (US) for the regents of the university of california
IPC Code(s): C07K16/28, A61K38/17, A61K39/00, A61P35/04
CPC Code(s): C07K16/2827
Abstract: a method of enhancing efficacy of mitogen-activated protein kinase inhibitor (mapki) therapy or immune checkpoint therapy (ict), as well as a method of suppressing melanoma brain metastasis in a subject, and a method of inhibiting intratumoral m2-like tumor associated macrophages (tams) or regulatory t cells (t) in a subject comprises (a) pretreating a subject appropriate for and in need of mapki therapy by administering one or more doses of ict to the subject; and (b) subsequent to the pretreating of (a), administering to the subject a combination of mapki and ict. the ict typically comprises an anti-pd-1 or anti-pd-l1 agent. optionally, the ict further comprises additional agents (such as anti-ctla4 and/or anti-lag3) to enhance the efficacy of mapki therapy.
Inventor(s): Anthony M. RUSH of San Diego CA (US) for the regents of the university of california, Nathan GIANNESCHI of Evanston IL (US) for the regents of the university of california, Carrie JAMES of San Diego CA (US) for the regents of the university of california
IPC Code(s): C08G61/02, C07H21/00, C07K14/00
CPC Code(s): C08G61/02
Abstract: provided herein are compositions and methods of making high density nucleic acid polymers.
Inventor(s): Hiromi Kumamaru of La Jolla CA (US) for the regents of the university of california, Mark Tuszynski of La Jolla CA (US) for the regents of the university of california
IPC Code(s): C12N5/0797
CPC Code(s): C12N5/0623
Abstract: spinal cord neural stem cells (nscs) have great potential to reconstitute damaged spinal neural circuitry. in some embodiments, derivation of spinal cord nscs from human pluripotent stem cells (hpscs) is described. these spinal cord nscs can differentiate into a diverse population of spinal cord neurons comprising multiple positions in the dorso-ventral axis, and can be maintained for prolonged time periods. after grafting into injured spinal cords, grafts may be rich with excitatory neurons, extend large numbers of axons over long distances, innervate their target structures, and enable robust corticospinal regeneration. in some embodiments, hpsc-derived spinal cord nscs enable a broad range of biomedical applications for in vitro disease modeling, and can provide a clinically-translatable cell source for spinal cord “replacement” strategies in several spinal cord disorders.
Inventor(s): Myeong-Je Cho of Oakland CA (US) for the regents of the university of california, Snigdha Poddar of Oakland CA (US) for the regents of the university of california, Brian J. Staskawicz of Oakland CA (US) for the regents of the university of california
IPC Code(s): C12N15/82, C12N5/04, C12N9/22, C12N15/11
CPC Code(s): C12N15/8207
Abstract: direct protein delivery to plant cells is a useful tool for both fundamental and applied research in plant science. in certain embodiments, the present invention provides a method of delivering a substance to plant tissue comprising biolistically delivering microparticles coated with the substance to the plant tissue to generate bombarded plant tissue.
Inventor(s): Zhibin Guan of Irvine CA (US) for the regents of the university of california, Dipankar Barpuzary of Irvine CA (US) for the regents of the university of california, Serxho Selmani of Irvine CA (US) for the regents of the university of california, Eric Schwartz of Irvine CA (US) for the regents of the university of california
IPC Code(s): C25B3/29, C08G83/00, C25B3/01, C25B11/095
CPC Code(s): C25B3/29
Abstract: the disclosure provides for methods and systems to create active supramolecular materials by using electrically fueled dissipative assembly, and applications thereof, including in electronic devices.
Inventor(s): Yu-Hwa Lo of San Diego CA (US) for the regents of the university of california, Zunming Zhang of La Jolla CA (US) for the regents of the university of california, Rui Tang of San Diego CA (US) for the regents of the university of california
IPC Code(s): G01N15/1433, G01N15/10
CPC Code(s): G01N15/1433
Abstract: disclosed are methods, systems, devices, materials, and structures for processing a heterogenous particle population. in some aspects, the disclosed technology uses a first imaging device to record first imaging data at high throughput and a particle placement assembly to place the particles exiting from the first imaging device at respective holder positions on a particle holder and acquire second imaging data to record such position information, and correlating the first imaging data of individual particles with position information recorded in the second imaging data.
Inventor(s): Divya Chalise of Berkeley CA (US) for the regents of the university of california, Richard Tee of Cerritos CA (US) for the regents of the university of california, Yuqiang Zeng of Berkeley CA (US) for the regents of the university of california, Sumanjeet Kaur of Pinole CA (US) for the regents of the university of california, Ravi S. Prasher of Danville CA (US) for the regents of the university of california
IPC Code(s): G01N25/18, G01B7/06
CPC Code(s): G01N25/18
Abstract: this disclosure provides systems, methods, and apparatus related to thermal properties measurement. in one aspect, a method includes providing a sensor. the sensor comprises a polymer film a metal line disposed on the polymer film. each end of the metal line is a contact pad. a thermal interface material is deposited on a first sample. the sensor is placed on the thermal interface material. a pressure is applied to the sensor. thermal conductivity of the first sample or thermal resistance of an interface between the first sample and a second sample is measured with the sensor using a 3 omega method.
Inventor(s): Abhejit Rajagopal of San Francisco CA (US) for the regents of the university of california, Nicholas Dwork of San Francisco CA (US) for the regents of the university of california, Peder E.Z. Larson of San Francisco CA (US) for the regents of the university of california, Thomas A. Hope of San Francisco CA (US) for the regents of the university of california
IPC Code(s): G06T11/00, G06T11/60, G06V10/764, G16H50/20
CPC Code(s): G06T11/005
Abstract: the present disclosure relates to techniques for fusing deep learning-based image reconstructions with noisy image measurements with provable assurances that the resulting improved image does not remove the information content of the original noisy measurements or image. particularly, aspects are directed to obtaining measurement data from an imaging modality, generating a base image by solving an optimization problem using at least a signal model and the measurement data, generating, using a deep-learning model, a predicted image based on the measurement data, selecting a modified operator based on the signal model, generating an enhanced image by solving the modified optimization problem using at least: (i) the base image or the measurement data, (ii) the signal model, (iii) the predicted image, and (iv) the modified operator, and outputting the enhanced image.
Inventor(s): Adam Gazzaley of San Francisco CA (US) for the regents of the university of california
IPC Code(s): G09B19/00, A61B3/11, A61B5/00, A61B5/0205, A61B5/024, A61B5/0533, A61B5/055, A61B5/083, A61B5/11, A61B5/16, A61B5/369, A63B24/00, A63B26/00, A63F13/211, A63F13/213, A63F13/85, G09B7/02
CPC Code(s): G09B19/003
Abstract: provided are methods that include presenting to a subject an embodied cognitive task that includes a cognitive component and a physical component. the methods further include assessing the subject's performance on each of the cognitive component and the physical component, and adapting the difficulty level of the embodied cognitive task based on the subject's performance on each of the cognitive component and the physical component. in certain aspects, the methods find use in enhancing cognition, physical fitness, or both, in a subject. also provided are methods of treating and diagnosing cognitive disorders. systems and computer readable media for practicing the methods of the present disclosure are also provided.
Inventor(s): Hartmut Gunter Haeffner of Berkeley CA (US) for the regents of the university of california, Sara Lambert Mouradian of Seattle WA (US) for the regents of the university of california, Eli Magidash of Berkeley CA (US) for the regents of the university of california, Nicole Sarah Greene of Berkeley CA (US) for the regents of the university of california, Zhao Zhang of Beijing (CN) for the regents of the university of california
IPC Code(s): G21K1/00, G02F1/33, G02F1/35, G06N10/40
CPC Code(s): G21K1/003
Abstract: in accordance with a method for individually addressing qubits in a set of qubits, a plurality of qubits is provided that each have two internal states representing a unit of quantum information. a transition between the two internal states of each qubit is caused by a two-photon raman transition. each of n ones of the qubits in the plurality of qubits are individually addressed using one of n pairs of laser beams, respectively, n being an integer greater than or equal to two. the laser beams in each of the n pairs have a frequency difference equal to a qubit transition frequency that represents a difference in frequency between the two internal states of the qubits. the laser beams in each pair of laser beams operate at different frequencies than the laser beams in every other pair of laser beams.
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications on February 27th, 2025
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- A61B5/1486
- A61B5/0205
- A61B5/145
- CPC A61B5/1486
- The regents of the university of california
- A61K31/517
- A61P37/06
- C12N15/113
- CPC A61K31/517
- A61K35/16
- A61F9/00
- A61K9/00
- A61K47/10
- A61K47/36
- CPC A61K35/16
- A61K35/745
- A61K31/198
- A61K31/337
- A61K31/4985
- A61K31/519
- A61K33/243
- A61K35/00
- A61K35/744
- A61K35/747
- A61K39/00
- A61K39/395
- A61P35/00
- CPC A61K35/745
- B01J20/22
- B01D53/02
- B01J20/28
- B01J20/30
- C07F5/06
- CPC B01J20/226
- C07C327/30
- A61K31/223
- A61K31/265
- A61P1/16
- C07C323/58
- CPC C07C327/30
- CPC C07F5/069
- C07K16/28
- A61K47/65
- A61K47/68
- G01N33/574
- CPC C07K16/28
- A61K38/17
- A61P35/04
- CPC C07K16/2827
- C08G61/02
- C07H21/00
- C07K14/00
- CPC C08G61/02
- C12N5/0797
- CPC C12N5/0623
- C12N15/82
- C12N5/04
- C12N9/22
- C12N15/11
- CPC C12N15/8207
- C25B3/29
- C08G83/00
- C25B3/01
- C25B11/095
- CPC C25B3/29
- G01N15/1433
- G01N15/10
- CPC G01N15/1433
- G01N25/18
- G01B7/06
- CPC G01N25/18
- G06T11/00
- G06T11/60
- G06V10/764
- G16H50/20
- CPC G06T11/005
- G09B19/00
- A61B3/11
- A61B5/00
- A61B5/024
- A61B5/0533
- A61B5/055
- A61B5/083
- A61B5/11
- A61B5/16
- A61B5/369
- A63B24/00
- A63B26/00
- A63F13/211
- A63F13/213
- A63F13/85
- G09B7/02
- CPC G09B19/003
- G21K1/00
- G02F1/33
- G02F1/35
- G06N10/40
- CPC G21K1/003
