THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications on August 8th, 2024
Patent Applications by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA on August 8th, 2024
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA: 18 patent applications
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA has applied for patents in the areas of A61K33/20 (3), A61P25/28 (3), C07K14/705 (2), H01G11/32 (2), A61K35/17 (2) A61K33/20 (3), A61F2/06 (1), A61K31/405 (1), A61K35/17 (1), A61K47/6901 (1)
With keywords such as: based, compound, methods, acids, peptide, layer, decomposition, such, dicarboxylate, and cells in patent application abstracts.
Patent Applications by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor(s): Yvonne Y. Chen of Los Angeles CA (US) for the regents of the university of california, Eugenia Zah of Los Angeles CA (US) for the regents of the university of california, Michael C. Jensen of Seattle WA (US) for the regents of the university of california
IPC Code(s): A61K35/17, A61K38/00, A61K39/00, C07K14/705, C07K14/725, C07K16/28, C07K16/46, C12N5/0783
CPC Code(s): A61K35/17
Abstract: a cd19-or-cd20 chimeric antigen receptor (car) protein construct is provided. also provided are nucleic acids encoding the cd19-or-cd20 car; and methods of use, e.g. in the treatment of b cell malignancies. the cd19-or-cd20 car of the invention is a bispecific car that can trigger t-cell activation upon detection of either cd19 or cd20 (or both). it is a single molecule that confers two-input recognition capability upon human t cells engineered to stably express this car.
20240261429. CPMV BINDING PEPTIDE_simplified_abstract_(the regents of the university of california)
Inventor(s): Nicole Steinmetz of La Jolla CA (US) for the regents of the university of california, Soo Khim Chan of La Jolla CA (US) for the regents of the university of california
IPC Code(s): A61K47/69, A61K47/62, C07K7/06, C07K14/005
CPC Code(s): A61K47/6901
Abstract: this disclosure provides a conjugate comprising a 7-mer peptide bound to the surface of a viral particle such as cowpea mosaic virus (cpmv). the c terminus of this peptide can be conjugated to desired molecules with the n terminus of the peptide interacting with cpmv surface.
Inventor(s): Jeffrey R. Long of Berkeley CA (US) for the regents of the university of california, Benjamin E. R. Snyder of Champaign IL (US) for the regents of the university of california, Ari B. Turkiewicz of Berkeley CA (US) for the regents of the university of california, Hiroyasu Furukawa of Berkeley CA (US) for the regents of the university of california, Maria V. Paley of Berkeley CA (US) for the regents of the university of california, Ever O. Velasquez of Berkeley CA (US) for the regents of the university of california, Matthew N. Dods of Berkeley CA (US) for the regents of the university of california
IPC Code(s): B01D53/04, B01J20/22, C01C1/02, C07F1/08, C07F11/00, C07F15/02
CPC Code(s): B01D53/0462
Abstract: a porous metal-organic framework m(dicarboxylate), where m=a divalent transition metal ion or alkaline earth metal ion, and (dicarboxylate)=a dicarboxylate linker with a layered two-dimensional structure with paddlewheel-type metal nodes forming a three-dimensional structure with rhombic channels along a c axis. the m(dicarboxylate) family of frameworks, where m=cu, fe, cr, mg, ca, mn, co, ni, zn, mo or cd and (dicarboxylate)=trans-1,4-cyclohexanedicarboxylate, 1,4-benzenedicarboxylate, 4,4â˛-biphenyldicarboxylate, or 2,3,5,6-tetrafluorobenzenedicarboxylate, reversibly binds ammonia via cooperative insertion into its metal-carboxylate bonds to form a dense, one-dimensional coordination polymer that has rapid adsorption kinetics, a comparatively large working capacity and minimal expansion upon ammonia capture.
Inventor(s): Lei Wang of San Francisco CA (US) for the regents of the university of california, Wei Sun of San Francisco CA (US) for the regents of the university of california, Paul C. Klauser of San Francisco CA (US) for the regents of the university of california, Li Cao of San Francisco CA (US) for the regents of the university of california, Bingchen Yu of San Francisco CA (US) for the regents of the university of california, Nanxi Wang of San Francisco CA (US) for the regents of the university of california, Shanshan Li of San Francisco CA (US) for the regents of the university of california, Michael J. Evans of South San Francisco CA (US) for the regents of the university of california
IPC Code(s): C07C305/26, C07C309/87, C07C309/88, C07C309/89
CPC Code(s): C07C305/26
Abstract: provided herein are inter alia, unnatural amino acids based on fluorosulfonyloxybenzoyl-l-lysine fsk, proteins comprising unnatural amino acids, nanobodies comprising unnatural amino acids based on fluorosulfate-l-tyrosine fsy, meta-fsy and ffy within cdr1, cdr2, or cdr3, biomolecule conjugates, and methods of making the proteins and biomolecule conjugates.
Inventor(s): Kole T. ROYBAL of San Francisco CA (US) for the regents of the university of california, Raymond LIU of San Francisco CA (US) for the regents of the university of california, Iowis ZHU of San Francisco CA (US) for the regents of the university of california
IPC Code(s): C07K14/705, A61K35/17, C12N5/0783
CPC Code(s): C07K14/705
Abstract: the present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. particularly, the new receptors, even though derived from notch, do not require the notch negative regulatory regions previously believed to be essential for the functioning of the receptors. the disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers.
Inventor(s): Nikolaos G. Sgourakis of Philadelphia PA (US) for the regents of the university of california, Sara O'Rourke of Scotts Valley CA (US) for the regents of the university of california
IPC Code(s): C07K14/74
CPC Code(s): C07K14/70539
Abstract: disclosed herein are novel glycosylated peptide receptive mhc-i complexes that allow for efficient production of glycosylated mhc-i multimers. such glycosylated peptide receptive mhc-i complexes include a single-chain mhc-i construct and are produced in mammalian expression systems (e.g., cho and hek cells) that allow for the glycosylation of the complexes at one or more native positions. multimers (e.g., tetramers) produced from the glycosylated peptide receptive mhc-i complexes provided herein advantageously allow for the identification of high-affinity t cell and natural killer cell receptors previously unidentified using traditional unglycosylated mhc tetramers.
Inventor(s): Tse Nga Ng of San Diego CA (US) for the regents of the university of california, Lulu Yao of San Diego CA (US) for the regents of the university of california, Jason Azoulay of Hattiesburg MS (US) for the regents of the university of california
IPC Code(s): C08G61/12, C08K3/04, H01B1/12, H01G11/32, H01G11/48, H01G11/86
CPC Code(s): C08G61/126
Abstract: embodiments of the presently disclosed technology provide a synergistic combination of a conjugated open-shell donor-acceptor polymer with a carbon-based compound (e.g., reduced graphene oxide) to produce a composite electrode material which demonstrates state-of-the-art capacitance and potential window, with excellent kinetics and cycle life. the conjugated open-shell donor-acceptor polymer may comprise a plurality of alternating electron-rich monomers (i.e., donors) and electron-deficient monomers (i.e., acceptors) bonded together via a conjugated backbone. the conjugated backbone may comprise a connection of ďż˝-orbitals of the plurality of monomers in alternating single and double bonds that facilitates unpaired electron delocalizationâthereby stabilizing charge for the polymer. the carbon-based compound of the composite electrode material may provide porous, conductive scaffolds for the composite electrode material, resulting in electrodes scalable to microns-thick films with fast kinetics.
Inventor(s): Holger WILLENBRING of San Francisco CA (US) for the regents of the university of california, Laure DUMONT of San Francisco CA (US) for the regents of the university of california, Yann MALATO of San Francisco CA (US) for the regents of the university of california
IPC Code(s): C12N15/86, A61K39/23, C07K14/47
CPC Code(s): C12N15/86
Abstract: the present invention relates to in vivo methods of delivering recombinant virions or viral vectors to a subject, including a human diagnosed with or suspected of having liver fibrosis. the disclosure also relates to methods in which recombinant virions, such as aav virions, are introduced into the myofibroblasts of the liver and to deliver therapeutic nucleic acids, including those nucleic acids necessary to differentiate a myofibroblast into a hepatocyte, thereby not only improving liver function but also reducing collagen deposition and thus liver fibrosis.
Inventor(s): Alysson Renato Muotri of La Jolla CA (US) for the regents of the university of california, Priscilla Davidson Negraes of San Diego CA (US) for the regents of the university of california, Cleber Trujillo of San Diego CA (US) for the regents of the university of california, Pinar Mesci of Carlsbad CA (US) for the regents of the university of california
IPC Code(s): G01N33/50, C12N5/0789
CPC Code(s): G01N33/5058
Abstract: the disclosure provides methods of making functional cortical organoids from somatic cells and stem cells and methods of using the functional organoids.
Inventor(s): Ailun Huang of Los Angeles CA (US) for the regents of the university of california, Maher F. El-Kady of Los Angeles CA (US) for the regents of the university of california, Richard B. Kaner of Pacific Palisades CA (US) for the regents of the university of california, Yuzhang Li of Los Angeles CA (US) for the regents of the university of california
IPC Code(s): H01G11/24, H01G11/26, H01G11/32, H01G11/46, H01G11/86, H01M4/131, H01M4/48, H01M4/62
CPC Code(s): H01G11/24
Abstract: disclosed herein are vanadium active materials, methods of making the same, and energy storage devices comprising the same. the vanadium active material may be incorporated into an electrode with a graphene scaffold, the graphene scaffold having a three-dimensional network of interconnected pores, a first vanadium oxide in a first oxidation state, and a second vanadium oxide in a second oxidation state.
Inventor(s): Shuji Nakamura of Santa Barbara CA (US) for the regents of the university of california, Steven P. DenBaars of Goleta CA (US) for the regents of the university of california
IPC Code(s): H01L21/02
CPC Code(s): H01L21/02334
Abstract: a iii-v or ii-vi compound based device is fabricated having one or more layers with an in-plane lattice constant or strain that is at least 20% biaxially relaxed, preferably more than 20% biaxially relaxed, more preferably 50% or more biaxially relaxed, and most preferably at least 70% biaxially relaxed. a iii-v or ii-vi compound based decomposition stop layer is created on or above a iii-v or ii-vi compound based decomposition layer, wherein the iii-v or ii-vi compound based decomposition stop layer has a higher sublimation temperature or melting point as compared to a lower sublimation temperature or melting point of the iii-v or ii-vi compound based decomposition layer, and a temperature increase decomposes the iii-v or ii-vi compound based decomposition layer. a iii-v or ii-vi compound based device structure is grown on or above the iii-v or ii-vi compound based decomposition stop layer.
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA patent applications on August 8th, 2024
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- A61K35/17
- A61K38/00
- A61K39/00
- C07K14/705
- C07K14/725
- C07K16/28
- C07K16/46
- C12N5/0783
- CPC A61K35/17
- The regents of the university of california
- A61K47/69
- A61K47/62
- C07K7/06
- C07K14/005
- CPC A61K47/6901
- B01D53/04
- B01J20/22
- C01C1/02
- C07F1/08
- C07F11/00
- C07F15/02
- CPC B01D53/0462
- C07C305/26
- C07C309/87
- C07C309/88
- C07C309/89
- CPC C07C305/26
- CPC C07K14/705
- C07K14/74
- CPC C07K14/70539
- C08G61/12
- C08K3/04
- H01B1/12
- H01G11/32
- H01G11/48
- H01G11/86
- CPC C08G61/126
- C12N15/86
- A61K39/23
- C07K14/47
- CPC C12N15/86
- G01N33/50
- C12N5/0789
- CPC G01N33/5058
- H01G11/24
- H01G11/26
- H01G11/46
- H01M4/131
- H01M4/48
- H01M4/62
- CPC H01G11/24
- H01L21/02
- CPC H01L21/02334
- A61K33/20
- A61P25/28
