THERAPEUTIC OLIGONUCLEOTIDES HAVING AN INTER-NUCLEOSIDE AMIDE LINKAGE

Organization Name

Inventor(s)

Afaf Helmy El-sagheer of Oxford (Oxfordshire) (GB)

Ysobel Ruth Baker of Oxford (Oxfordshire) (GB)

Pawan Kumar of Oxford (Oxfordshire) (GB)

THERAPEUTIC OLIGONUCLEOTIDES HAVING AN INTER-NUCLEOSIDE AMIDE LINKAGE

This abstract first appeared for US patent application 20250059537 titled 'THERAPEUTIC OLIGONUCLEOTIDES HAVING AN INTER-NUCLEOSIDE AMIDE LINKAGE

Original Abstract Submitted

the present invention relates to a therapeutic oligonucleotide having a 5′ and a 3′ end and comprising a sequence of nucleosides linked together by inter-nucleoside linkages, wherein: at least one inter-nucleoside linkage is an amide linker moiety; at least one inter-nucleoside linkage is a phosphorothioate linker moiety; and at least one nucleoside present in the oligonucleotide is a locked nucleoside; wherein the at least one locked nucleoside is directly attached to the 3′ end or the 5′ end of the amide linker moeity. the oligonucleotide has preferably structure (iia) or (llb):