NERVE GRAFTS AND METHODS OF PREPARATION THEREOF

Abstract: tissue grafts with reduced regenerative potential, methods of preparing such grafts, and related kits and methods of treatment are described. the method may include treating tissue with a digestion solution comprising trypsin, alpha-chymotrypsin (act) and optionally ethylenediaminetetraacetic acid (edta) to substantially remove one or more susceptible proteins from the tissue. the method may also include washing the treated tissue with a buffer solution and/or with a serine-containing serum. nerve grafts prepared according to the disclosed methods may inhibit, or lessen (e.g., provide for reduced) neuroma formation and/or axonal outgrowth after implantation.

IPC:

CPC: A61L27/3675,