Coronavirus T Cell Epitopes, Megapools and Uses Thereof

Abstract: the present disclosure includes compositions and methods for detecting the presence of: a coronavirus or an immune response relevant to a coronavirus infection including t cells responsive to one or more coronavirus peptides or proteins comprising, consisting of, or consisting essentially of: one or more amino acid sequences selected from those sequences set forth in tables 1 to 10 (seq id nos: 1 to 3522), or a subsequence, portion, homologue, variant or derivative thereof; a fusion protein; a pool of 2 or more peptides; or a polynucleotide that encodes one or more peptides or proteins, comprising, consisting of, or consisting essentially of one or more amino acid sequences set forth in tables 1 to 10 (seq id nos: 1 to 3522), or a subsequence, portion, homologue, variant or derivative thereof. the disclosure further provides vaccines, diagnostics, therapies, and kits, comprising such proteins or peptides.

Inventor(s): Alessandro Sette, Shane Crotty, Bjoern Peters, John Sidney, Alba Grifoni, Daniela Weiskopf, Ricardo Da Silva Antunes

CPC Classification: G01N33/56972 (for microorganisms, e.g. protozoa, bacteria, viruses)

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