DEVICE AND METHOD FOR ISOLATION AND DETECTION OF TARGETS IN A SAMPLE

Abstract: embodiments disclosed herein relate to methods and devices for detecting targets in a sample. a plurality of targets in a sample and a plurality of particles may be provided in a volume and configured to bind to one another to form bound particle-target complexes. in some embodiments, the volume may also include one or more density gradient or two or more density media which may form an interface. the bound particle-target complexes may experience a density shift and separation in the density media relative to unbound targets and/or unbound particles. in some such embodiments, the bound particle-target complexes may settle at the interface formed by the density media. in some embodiments, the separated bound particle-target complexes may then undergo concentration, extraction, and analysis steps.

Inventor(s): Rohit N. Karnik, Emily Barret Hanhauser, Michael Bono, Mary Claire Strawser

CPC Classification: G01N33/54326 ({Magnetic particles})

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