Use of Trinucleotide Repeat RNAs To Treat Cancer

Abstract: disclosed are compositions and methods related to rna interference (rnai) and the use of rnai active sequence for treating diseases and disorders. particular disclosed are toxic rnai active sequences such as sirna and shrna for killing cancer cells. the disclosed toxic rnai active sequences typically include trinucleotide repeats and preferentially target the expression of multiple essential genes for cell survival and/or growth.

Inventor(s): Marcus E. Peter, Andrea E. Murmann

CPC Classification: C12N15/1138 ({against receptors or cell surface proteins})

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