MICROGEL COMPOSITIONS AND THEIR USE AS LUBRICANTS

Abstract: a microgel composition comprising micron-sized particles of poly(acrylic acid) in which at least a portion of carboxylic acid groups in the poly(acrylic acid) are crosslinked as shown in the following structure: wherein: l is a linear or branched polyalkylene glycol-containing linker, or l more particularly has the following formula: —o—[ch(r)ch(r′)—o]—; r and r′ are independently selected from h and ch; and x is an integer of 1-50; wherein the micron-sized particles have an average diameter of at least 1 micron. methods for imparting lubricity to a biological tissue and methods for treating an articular disease or condition (e.g., arthritis or osteoarthritis) by administering the microgel composition are also described.

Inventor(s): David PUTNAM, Ruben TRUJILLO

CPC Classification: C08F120/06 (MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS)

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