ANTI-EGFR ANTIBODIES, ANTI-CMET ANTIBODIES, ANTI-VEGF ANTIBODIES, MULTISPECIFIC ANTIBODIES, AND USES THEREOF

Abstract: the disclosure provides antibodies and fragments targeting egfr, vegf, pd-l1, or cmet. the disclosure also provides multispecific antibodies that comprise a first variable domain that can bind the epidermal growth factor receptor (egfr), a second variable domain that can bind cmet, and a third variable domain that can bind pd-l1 or vegf. the multispecific antibodies are effective in treating cancers and/or other diseases, disorders, and conditions where pathogenesis is mediated by egfr, vegf or pd-l1, and cmet.

Inventor(s): Pu PU, Songling ZHANG, Ying JIN, Maria P. MACWILLIAMS, Man-Cheong FUNG, Mark L. CHIU

CPC Classification: C07K16/2863 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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