CD3-BINDING PROTEINS AND METHODS OF USE THEREOF

Abstract: the present disclosure includes target-binding proteins having heavy chain variable domains and light chain variable domains with specific sequences that bind to cd3 epsilon and wherein the heavy chain variable domains and the light chain variable domains are disposed within one or more polypeptides. the present disclosure also includes compositions, nucleic acids, vectors, cells, and methods of making and using the proteins, compositions, and nucleic acids.

Inventor(s): Madan M. PAIDHUNGAT, Sayantan MITRA, Leila M. BOUSTANY, Ellaine Anne Mariano FOX, Trang T.T. VU, Laurie WONG, Veena VINOD, Nicole G. LAPUYADE, Melissa TRIEU, Vijit DALAL

CPC Classification: C07K16/2809 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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