METHOD FOR INCREASING HALF-LIFE OF BOTULINUM TOXIN TYPE A LIGHT CHAIN PROTEIN

Abstract: the present invention relates to: a method for increasing the half-life of a botulinum toxin type a light chain (aut-bt-lc) protein, the method comprising substituting one or more lysine residues present in the amino acid sequence of the botulinum toxin type a light chain (bt-lc) protein; or a botulinum toxin type a light chain (aut-bt-lc) protein having an increased half-life. the protein having an increased half-life according to the present invention may be used in a cosmetic composition and a pharmaceutical composition.

Inventor(s): Myung-Sun KIM, Hye-Young LIM, Su-Kyung OH, Jae-Woo LEE, Sung-Ryul BAE, Seung-In CHOI

CPC Classification: C07K14/33 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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