SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF

Abstract: provided herein are compounds that modulate glucocerebrosidase (gcase), an enzyme whose activity is associated with neurological diseases and disorders (e.g., gaucher's disease, parkinson's disease). also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating gcase-related diseases and disorders (e.g., gaucher's disease, parkinson's disease) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Inventor(s): Kevin Hunt, Jianbin Zheng, Sida Shen

CPC Classification: C07D519/00 (HETEROCYCLIC COMPOUNDS (macromolecular compounds ))

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