ANCHORED CELL CONSTRUCT CULTURE

Abstract: scaffold-free cell constructs are made from cell sheets. a device has a membrane and anchors located inside of a perimeter or wall of the membrane. the membrane allows cell attachment followed by detachment of cells and secreted ecm as a cell sheet. in a method, cells are grown into a cell sheet. the cell sheet is located around two or more anchors. the cell sheet remodels into a cell construct of a different shape attached to the anchors. when a cell sheet is grown in the device, the anchors form and pass through openings in the cell sheet. detaching the cell sheet locates the cell sheet around the around the anchors. the cell construct can be used with or without decellularization and while attached to the anchors, for example as in vitro models, or after being removed from the anchors, for example in regenerative medicine or tissue engineering.

Inventor(s): Alireza SHAHIN-SHAMSABADI

CPC Classification: A61L27/3826 (METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed ; preserving, e.g. sterilising, food or foodstuffs ; preparations for medical, dental or toiletry purposes ))

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