Metallophore-Radionuclide Complex as Nuclear Imaging Contrast Agents

Abstract: the present invention involves a method of targeted imaging of a bacterial infection in a subject. in one embodiment, the method includes administering pyochelin (pch) bound to a radiometal to the subject and imaging the infected area of the subject using a positron emission tomography-computed tomography (pet/ct) scan. in one embodiment, the pyochelin bound to a radiometal is selected from the group consisting of copper-64 bound pyochelin and gallium-68 bound pyochelin.

Inventor(s): Nalinikanth Kotagiri, Alec Ventrola

CPC Classification: A61K51/0478 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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