20250228964. Preparation Therapeutic Exos (LONZA SALES AG)
PREPARATION OF THERAPEUTIC EXOSOMES USING MEMBRANE PROTEINS
Abstract: the present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. it also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. the methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.
Inventor(s): Kevin P. DOOLEY, Rane A. HARRISON, Russell E. MCCONNELL, Ke XU, Damian J. HOUDE, Nikki ROSS, Sonya HAUPT, John D. KULMAN, Douglas E. WILLIAMS
CPC Classification: A61K47/6917 (the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit)
Search for rejections for patent application number 20250228964
- Patent Applications
- LONZA SALES AG
- CPC A61K47/6917
- Kevin P. DOOLEY of Boston MA US
- Rane A. HARRISON of Belmont MA US
- Russell E. MCCONNELL of Brighton MA US
- Ke XU of Sudbury MA US
- Damian J. HOUDE of Plymouth MA US
- Nikki ROSS of Cambridge MA US
- Sonya HAUPT of Cambridge MA US
- John D. KULMAN of Belmont MA US
- Douglas E. WILLIAMS of Boston MA US