TRANSFERRIN-BASED LYSOSOME TARGETING DEGRADERS

Abstract: provided herein are bifunctional lysosomal targeting degraders including a ligand configured to bind to transferrin receptor as a shuttle molecule for lysosome degradation, and a protein-binding moiety configured to bind a membrane or extracellular protein of interest, wherein the bifunctional lysosome targeting degraders can be recycled back out of cells and be catalytic. the bifunctional degraders find use, e.g., for selectively targeted degradation of membrane or extracellular proteins via the endosomal/lysosomal pathway. also provided herein are compositions comprising the bifunctional degraders, as well as methods of using the bifunctional degraders.

Inventor(s): Weiping Tang, Yaxian Zhou

CPC Classification: A61K47/6811 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

Search for rejections for patent application number 20250228959