INTRACELLULAR TARGETING OF OLIGONUCLEOTIDES

Abstract: compounds are provided include a cell penetrating peptide, a therapeutic oligonucleotide, and a carbohydrate targeting moiety. the compounds may also include an exocyclic peptide. the compounds may be targeted to liver cells. the therapeutic oligonucleotide may be an oligonucleotide for treating a disease or disorder associated with a liver cell.

Inventor(s): Ziqing Qian, Mahboubeh Kheirabadi, Matthew Streeter

CPC Classification: A61K47/64 (Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers ))

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