METAL-ORGANIC FRAMEWORKS AS SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS

Abstract: the present invention relates to a composition comprising a metal-organic framework, one or more emulsifier(s), one or more lipid(s) and one or more co-emulsifier(s). furthermore, the present invention relates to a method for preparing a microemulsion in response to a physical- and/or chemical stimulus and to a method for increasing the solubility of a pharmaceutically active ingredient in a solvent and/or for improving the bioavailability of a pharmaceutically active ingredient and/or for preparing a self-microemulsifying drug delivery system.

Inventor(s): Lena SCHELLER, Lorenz MEINEL, Tess LUEHMANN

CPC Classification: A61K47/24 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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