ADENOVIRAL VECTORS ENCODING HEPATITIS B VIRAL ANTIGENS FUSED TO HERPES VIRUS GLYCOPROTEIN D AND METHODS OF USING THE SAME

Abstract: provided herein are non-naturally occurring variants of the hepatitis b virus (hbv) core protein, the hbv polymerase n-terminal domain, and the hbv polymerase c-terminal domain, as well as immunogenic fragments thereof. fusion proteins comprising the hbv variants fused to a herpes simplex virus (hsv) glycoprotein (gd) sequence, as well as methods of using the fusion proteins, are also provided.

Inventor(s): Hildegund CJ ERTL, Colin Stephen MAGOWAN

CPC Classification: A61K39/292 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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