METHODS OF CONTROLLING BODY WEIGHT AND/OR ENERGY EXPENDITURE

Abstract: described herein are a method of increasing energy expenditure level in a subject, a method of reducing body weight in a subject, a method of decreasing the amount of white adipose (wat) tissue and/or promoting browning of wat in a subject, and/or a method of improving glucose tolerance and/or insulin sensitivity in a subject. each of the methods includes downregulating the level and/or activity of augmentor � (aug�), or downregulating the level and/or activity of anaplastic lymphoma kinase (alk) in the subject. also described herein are a method of decreasing energy expenditure level in a subject, and/or a method of increasing body weight in a subject. each of the methods includes upregulating the level and/or activity of aug�, or upregulating the level and/or activity of alk in the subject.

Inventor(s): Joseph Schlessinger, Tamas Horvath, Mansoor Ahmed, Navjot Kaur

CPC Classification: A61K38/19 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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