DISTINCT CD8+ T CELL PROGRAMMING IN THE TUMOR MICROENVIRONMENT CONTRIBUTES TO SEX BIAS IN CANCER

Abstract: disclosed are methods for reducing t cell exhaustion and/or treating male sex biased cancers through the administration of agents that inhibit androgen receptor. in some aspects the methods further comprise the detection of a male sex biased cancer and/or t cell exhaustion via detection of tox+ and/or t cell factor 1 (tcf1)+ t cells in the tumor microenvironment.

Inventor(s): Zihai LI, Dongjun CHUNG

CPC Classification: A61K38/08 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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