COMPOSITIONS AND METHODS FOR TREATMENT OF SEPSIS-RELATED DISORDERS

Abstract: a method comprising administering, to a subject in need thereof, an effective amount of a nucleotide effective to disrupt one or more pathways leading to sepsis. the nucleotide may be a nitric oxide disruptor effective to decrease the expression of inducible nitric oxide synthase. the nitric oxide disrupter may comprise a polynucleotide strand exhibiting at least 70% sequence identity to one of sequence id no. 1 through sequence id no. 47. additionally or alternatively, the nucleotide may be an � disintegrin and metalloproteinase (adam) enzyme inhibitor effective to decrease the expression of adam enzyme. the adam enzyme inhibitor may comprise a polynucleotide strand exhibiting at least 70% sequence identity to one of sequence id no. 48 through sequence id no. 56.

Inventor(s): John Mansell

CPC Classification: A61K31/713 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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