METHODS OF USING ATR INHIBITORS

Abstract: disclosed are methods of treating a cancer in a subject using an atr inhibitor wherein the cancer has been previously identified as a cancer having a loss of function of stag2, setd2, cdk12, atrip, rev3l, rad17, chtf8, fzr1, rad51b, rad51c, rad51d, palb2, rnaseh2a, or rnaseh2b. also disclosed are methods of inducing cell death in an aberrant cancer cell having a loss of function of stag2, setd2, cdk12, atrip, rev3l, rad17, chtf8, fzr1, rad51b, rad51c, rad51d, palb2, rnaseh2a, or rnaseh2b by contacting the cell with an effective amount of an atr inhibitor.

Inventor(s): Theo GOULLET DE RUGY, Stephen MORRIS, Jordan YOUNG, Michal ZIMMERMANN, Dominik GLODZIK

CPC Classification: A61K31/5377 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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