SYNERGIC AND STABLE PHARMACEUTICAL COMPOSITION OF AN NSAID AND AN OPIOID ANALGESIC FOR PAIN AND INFLAMMATION

Abstract: the present invention relates to pharmaceutical compositions comprising etoricoxib and tramadol, or a pharmaceutically acceptable salt thereof, for the treatment of pain, which in addition to offering the possibility of an analgesic effect with a decrease in adverse events due to the reduction of the dose of one or both compounds, presents an improved stability, maintaining the dissolution and bioavailability of the composition to be administered; the composition manages to overcome the technological complexity that lies in having a drug with high sensitivity to light and humidity (tramadol), together with another fat-soluble drug with poor flow and excessive adhesiveness (etoricoxib), in a dispensing media in which their absorption is not affected through a water-free process, without affecting the release of both drugs.

Inventor(s): Jorge Alejandro González Canudas, Marco Antonio Espinosa Olivares, Cecilia Jannette Muñoz Martínez, Paola Yazmín Ollervides Rubio, Guillermo Sander Padilla

CPC Classification: A61K31/135 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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