SOLID COMPOSITION COMPRISING SOLUBILISED BRADYKININ B2-RECEPTOR ANTAGONISTS

Abstract: the invention relates to solid dispersions for oral administration comprising a bradykinin b2 receptor antagonist having a chemical structure according to formula (1), or a salt or solvate thereof, wherein r is deuterium or hydrogen: formula (1) such as (s)-/v-(1-deutero-1-(3-chloro-5-fluoro-2-((2-methyl-4-(1-methyl-1/f-1,2,4-triazol-5-yl)quinolin-8-yloxy)methyl)phenyl)ethyl)-2-(di-fluoromethoxy)acetamide. the solid dispersions comprise the bk b2 receptor antagonist in the amorphous form and homogeneously dispersed in a pharmaceutically acceptable polymer. furthermore, methods for preparation and uses of the solid dispersions, including therapeutic uses, are provided.

Inventor(s): Christoph GIBSON

CPC Classification: A61K9/2054 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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