COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS

Abstract: the disclosure features novel lipids and compositions involving the same. nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and peg lipids. nanoparticle compositions further including therapeutic and/or prophylactics such as rna are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

Inventor(s): Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY

CPC Classification: A61K9/1272 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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